Product Name
Cohesin subunit SA-3 (STAG3), Polyclonal Antibody
Full Product Name
Cohesin subunit SA-3
Product Synonym Names
SCC3 homolog 3; Stromal antigen 3; Stromalin-3
Product Gene Name
anti-STAG3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UJ98
Other Notes
Small volumes of anti-STAG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for STAG3. It may not necessarily be applicable to this product.
NCBI Accession #
Q9UJ98.2
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UniProt Primary Accession #
Q9UJ98
[Other Products]
UniProt Secondary Accession #
Q8NDP3; A6H8Z1; B4DZ10; D6W5U8; H7BYK9[Other Products]
UniProt Related Accession #
Q9UJ98[Other Products]
Molecular Weight
132,319 Da[Similar Products]
NCBI Official Full Name
Cohesin subunit SA-3
NCBI Official Synonym Full Names
stromal antigen 3
NCBI Official Symbol
STAG3??[Similar Products]
NCBI Protein Information
cohesin subunit SA-3
UniProt Protein Name
Cohesin subunit SA-3
UniProt Synonym Protein Names
SCC3 homolog 3; Stromal antigen 3; Stromalin-3
UniProt Gene Name
STAG3??[Similar Products]
NCBI Summary for STAG3
The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]
UniProt Comments for STAG3
STAG3: Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Belongs to the SCC3 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: extracellular space; nucleus; synaptonemal complex
Biological Process: synaptonemal complex assembly
Disease: Premature Ovarian Failure 8
Research Articles on STAG3
1. STAG3 truncating variant as the cause of primary ovarian insufficiency has been found in two sisters in a consanguineous Lebanese family.
Precautions
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