Full Product Name
ASMT Polyclonal Antibody
Product Synonym Names
ASMTY; HIOMT; HIOMTY
Product Gene Name
anti-ASMT antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P46597
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Immunogen
A synthetic peptide of human ASMT
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at 4 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-ASMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASMT antibody
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene.
Product Categories/Family for anti-ASMT antibody
Primary antibody
Applications Tested/Suitable for anti-ASMT antibody
Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-ASMT antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
FC: 1:20 - 1:50
Western Blot (WB) of anti-ASMT antibody
Western blot analysis of extracts of various cell lines, using ASMT antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 15s.
NCBI/Uniprot data below describe general gene information for ASMT. It may not necessarily be applicable to this product.
NCBI Accession #
P46597.1
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UniProt Primary Accession #
P46597
[Other Products]
UniProt Secondary Accession #
Q16598; Q5JQ72; Q5JQ73; B2RC33[Other Products]
UniProt Related Accession #
P46597[Other Products]
NCBI Official Full Name
Acetylserotonin O-methyltransferase
NCBI Official Synonym Full Names
acetylserotonin O-methyltransferase
NCBI Official Symbol
ASMT??[Similar Products]
NCBI Official Synonym Symbols
ASMTY; HIOMT; HIOMTY
??[Similar Products]
NCBI Protein Information
acetylserotonin O-methyltransferase
UniProt Protein Name
Acetylserotonin O-methyltransferase
UniProt Synonym Protein Names
Hydroxyindole O-methyltransferase; HIOMT
Protein Family
Acetylserotonin O-methyltransferase
UniProt Gene Name
ASMT??[Similar Products]
UniProt Synonym Gene Names
HIOMT??[Similar Products]
NCBI Summary for ASMT
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
UniProt Comments for ASMT
ASMT: Produces melatonin (N-acetyl-5-methoxytryptamine) from N-acetylserotonin. Belongs to the methyltransferase superfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - tryptophan; EC 2.1.1.4; Methyltransferase
Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2
Cellular Component: cytosol
Molecular Function: acetylserotonin O-methyltransferase activity; identical protein binding; O-methyltransferase activity; protein homodimerization activity; S-methyltransferase activity
Biological Process: indolalkylamine biosynthetic process; melatonin biosynthetic process; translation
Research Articles on ASMT
1. Even when considering only high-grade glioma patients, a low ASMT:CYP1B1 value, which suggests decreased melatonin and enhanced aggressiveness, was strongly associated with poor survival. Overall, our data reveal the prognostic value of the melatonergic system of gliomas and provide insights into the therapeutic role of melatonin.
Precautions
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Disclaimer
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