Product Name
B4GALT5, Blocking Peptide
Full Product Name
B4GALT5 Blocking Peptide (C-term)
Product Synonym Names
Beta-1;4-galactosyltransferase 5; Beta-1;4-GalTase 5; Beta4Gal-T5; b4Gal-T5; 241-; Beta-1;4-GalT II; UDP-Gal:beta-GlcNAc beta-1;4-galactosyltransferase 5; UDP-galactose:beta-N-acetylglucosamine beta-1;4-galactosyltransferase 5; B4GALT5
Product Gene Name
B4GALT5 blocking peptide
[Similar Products]
B4GALT5 peptide (MBS9230864) is used for blocking the activity of B4GALT5 antibody (MBS9207045)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43286
Specificity
The synthetic peptide sequence is selected from aa 339-350 of HUMAN B4GALT5
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note: Trans cisternae of Golgi stack
Tissue Location
Ubiquitously expressed.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of B4GALT5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
B4GALT5 blocking peptide
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
NCBI/Uniprot data below describe general gene information for B4GALT5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004767.1
[Other Products]
NCBI GenBank Nucleotide #
NM_004776.3
[Other Products]
UniProt Primary Accession #
O43286
[Other Products]
UniProt Secondary Accession #
Q2M394; Q9UJQ8; E1P625[Other Products]
UniProt Related Accession #
O43286[Other Products]
Molecular Weight
45,119 Da
NCBI Official Full Name
beta-1,4-galactosyltransferase 5
NCBI Official Synonym Full Names
beta-1,4-galactosyltransferase 5
NCBI Official Symbol
B4GALT5??[Similar Products]
NCBI Official Synonym Symbols
gt-V; B4Gal-T5; beta4Gal-T5; beta4GalT-V; BETA4-GALT-IV
??[Similar Products]
NCBI Protein Information
beta-1,4-galactosyltransferase 5
UniProt Protein Name
Beta-1,4-galactosyltransferase 5
UniProt Synonym Protein Names
Beta-1,4-GalT II; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5
Protein Family
Beta-1,4-galactosyltransferase
UniProt Gene Name
B4GALT5??[Similar Products]
UniProt Synonym Gene Names
Beta-1,4-GalTase 5; Beta4Gal-T5; b4Gal-T5??[Similar Products]
UniProt Entry Name
B4GT5_HUMAN
NCBI Summary for B4GALT5
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq, Jul 2008]
UniProt Comments for B4GALT5
B4GALT5: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Belongs to the glycosyltransferase 7 family.
Protein type: Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; EC 2.4.1.-; Transferase
Chromosomal Location of Human Ortholog: 20q13.1-q13.2
Cellular Component: Golgi membrane
Molecular Function: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; galactosyltransferase activity
Biological Process: keratan sulfate biosynthetic process; O-glycan processing
Research Articles on B4GALT5
1. B4GALT1 and B4GALT5, two members of B4GALT gene family, are involved in the development of multidrug resistance of human leukemia cells.
Precautions
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Disclaimer
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