Product Name
G Protein Antagonist (GPR55), Peptide
Full Product Name
G Protein Antagonist
Product Gene Name
GPR55 peptide
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (231772043..231789953, complement). Location: 2q37
3D Structure
ModBase 3D Structure for Q9Y2T6
Purity/Purification
Highly Purified
~95%. Purified by HPLC.
Form/Format
Supplied as a lyophilized powder.
Sequence (linear)
Pyr-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of GPR55 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for GPR55 peptide
Molecular Biology; MB-Peptides
NCBI/Uniprot data below describe general gene information for GPR55. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005674.2
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NCBI GenBank Nucleotide #
NM_005683.3
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UniProt Primary Accession #
Q9Y2T6
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UniProt Secondary Accession #
Q8N580[Other Products]
UniProt Related Accession #
Q9Y2T6[Other Products]
Molecular Weight
36,637 Da[Similar Products]
NCBI Official Full Name
G-protein coupled receptor 55
NCBI Official Synonym Full Names
G protein-coupled receptor 55
NCBI Official Symbol
GPR55??[Similar Products]
NCBI Protein Information
G-protein coupled receptor 55
UniProt Protein Name
G-protein coupled receptor 55
Protein Family
G-protein coupled receptor
UniProt Gene Name
GPR55??[Similar Products]
UniProt Entry Name
GPR55_HUMAN
NCBI Summary for GPR55
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
UniProt Comments for GPR55
Function: May be involved in hyperalgesia associated with inflammatory and neuropathic pain
By similarity. Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. Ref.7
Subcellular location: Cell membrane; Multi-pass membrane protein Ref.5.
Tissue specificity: Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts. Ref.1 Ref.7
Miscellaneous: The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Sequence caution: The sequence AAD22410.1 differs from that shown. Reason: Frameshift at positions 132 and 142.
Research Articles on GPR55
1. Data suggest that GPR55 is functionally expressed in vascular endothelium/platelets and is involved in regulation of calcium signaling; as suspected, lysophosphatidylinositol is a ligand/agonist for GPR55.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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