Full Product Name
GP5 Antibody
Product Synonym Names
GP5; Platelet glycoprotein V; GPV; Glycoprotein 5; CD42d
Product Gene Name
anti-GP5 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P40197
Species Reactivity
Human, Mouse, Rat
Specificity
GP5 Antibody detects endogenous levels of GP5 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human GP5.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-GP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GP5 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-GP5 antibody
WB: 1:500~1:1000
ELISA: 1:10000
Western Blot (WB) of anti-GP5 antibody
Western Blot analysis of extracts from Hela cells using GP5 Antibody.
NCBI/Uniprot data below describe general gene information for GP5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004479.1
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NCBI GenBank Nucleotide #
NM_004488.2
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UniProt Primary Accession #
P40197
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UniProt Secondary Accession #
D1MER9[Other Products]
UniProt Related Accession #
P40197[Other Products]
NCBI Official Full Name
platelet glycoprotein V
NCBI Official Synonym Full Names
glycoprotein V platelet
NCBI Official Symbol
GP5??[Similar Products]
NCBI Official Synonym Symbols
GPV; CD42d
??[Similar Products]
NCBI Protein Information
platelet glycoprotein V
UniProt Protein Name
Platelet glycoprotein V
UniProt Synonym Protein Names
Glycoprotein 5; CD_antigen: CD42d
Protein Family
Glycoprotein
UniProt Gene Name
GP5??[Similar Products]
UniProt Synonym Gene Names
GPV??[Similar Products]
NCBI Summary for GP5
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]
UniProt Comments for GP5
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
Research Articles on GP5
1. Studies indicate that platelets from Bernard-Soulier syndrome (BSS) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha disulfide linked to GPIbbeta, and noncovalently associated with GPIX and GPV.
Precautions
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Disclaimer
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