Full Product Name
Anti-BBS10 Antibody
Product Synonym Names
C12orf58; Bardet-Biedl syndrome 10 protein
Product Gene Name
anti-BBS10 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8TAM1
Species Reactivity
Human, Mouse
Specificity
Recognizes endogenous levels of BBS10 protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human BBS10
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-BBS10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BBS10 antibody
Rabbit polyclonal antibody to BBS10
Applications Tested/Suitable for anti-BBS10 antibody
Western Blot (WB)
Application Notes for anti-BBS10 antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-BBS10 antibody
Western blot analysis of BBS10 expression in A431 (A), Hela (B), mouse liver (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for BBS10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_078961.3
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NCBI GenBank Nucleotide #
NM_024685.3
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UniProt Primary Accession #
Q8TAM1
[Other Products]
UniProt Secondary Accession #
Q96CW2; Q9H5D2[Other Products]
UniProt Related Accession #
Q8TAM1[Other Products]
Molecular Weight
80,838 Da
NCBI Official Full Name
Bardet-Biedl syndrome 10 protein
NCBI Official Synonym Full Names
Bardet-Biedl syndrome 10
NCBI Official Symbol
BBS10??[Similar Products]
NCBI Official Synonym Symbols
C12orf58
??[Similar Products]
NCBI Protein Information
Bardet-Biedl syndrome 10 protein
UniProt Protein Name
Bardet-Biedl syndrome 10 protein
Protein Family
Bardet-Biedl syndrome 10 protein
UniProt Gene Name
BBS10??[Similar Products]
UniProt Synonym Gene Names
C12orf58??[Similar Products]
NCBI Summary for BBS10
This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. [provided by RefSeq, Jan 2010]
UniProt Comments for BBS10
Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.
Research Articles on BBS10
1. we report here, for the first time, in Indian population, a novel, different profile of mutations in BBS genes (BBS3, BBS9, BBS10 and BBS2) compared to worldwide (BBS1 and 10) reports.
Precautions
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