For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Purified by peptide affinity column containing 2% BSA and 0.02% NaN3

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C.

Small volumes of anti-CDKN2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal CDKN2A (1) antibody was raised against a peptide at the C terminal residues of human CDKN2A protein.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Peptide ELISA (EIA), Immunohistochemistry (IHC)

Peptide ELISA: 1:10,000-1:40,000
IHC: 1:50-200

8,731 Da

cyclin dependent kinase inhibitor 2A

cyclin-dependent kinase inhibitor 2A

Cyclin-dependent kinase inhibitor 2A

CDK4I; MTS-1; p16-INK4; p16INK4A??[Similar Products]

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

(1) Shete, S., Hosking, F.J., Robertson, L.B. Genome-wide association study identifies five susceptibility loci for glioma.Nat. Genet. 41 (8), 899-904 (2009).

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