Product Name
Dendrin (Ddn), Recombinant Protein
Full Product Name
Recombinant Mouse Dendrin (Ddn)
Product Gene Name
Ddn recombinant protein
[Similar Products]
Product Synonym Gene Name
Ddn[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-710aa, full length protein
Sequence
MLDGPLFSEG PDSPRELQDE ESGSCLWVQK SKLLVIEVKT ISCHYSRRAP SRQSMDIQAS YWARGPQSRT CRLRPGSPEP PPRRPWASRV LQEATNWRAG PPAEVRAREQ EKRKAASQER EAKETERKRR KAGGARRSPL GQPRPEPRNA LRAAQPTGFP VFSRPERFGQ VGRAPRPSVL PQGDPGVAWA GPWGGRRPGP PSYEAHLLLR GSAGTAPRRR WDRPPPYVAP PSYEGPHRTL GTKRGPELSR APTSSAPVPA TTRTEGGRTK KRLDPRIYRD VLGAWGLRQG RGLLGGAPGC TAARARPESC KGAIEKSSGL VAAGLNSAGD SHSQGKTTGG PGTDAALSRS AISSPPRPVP RSRQHLRGSR KGKEGSEQIW LPTCWLASPK KPPVRHSQTL PRPWAPGGTG WKESLGQREG AEHETLEVWK VTRRAHTLPR ISRGPAGREG IFVIDATCVV IKSQYVPTPR TQQGQLVPSG ESCSVSDSLS QPKPCHEEEG EGAAANPSVC QKRLLSSRVL NQPSEGRECE AEVGQQGDSS LEERSSSGLG FPVGEVNPRD APTQPGSQEH PTLGPAAPVC AGSLKGSEAA GVPRRAGGGW ARTPGPYAGA LREAVSRIRR HTAPDSDSDE AEDLSVHSGS SDGSDTDAPG ASWRNERTLP ALGNTRPREG GKTAGLSDSI REIVDVISQT EEGFIREDTR KTPQGNRERE
3D Structure
ModBase 3D Structure for Q80TS7
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Ddn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Ddn. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001013763.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001013741.1
[Other Products]
UniProt Primary Accession #
Q80TS7
[Other Products]
UniProt Secondary Accession #
Q3TPT2; Q3TY46[Other Products]
UniProt Related Accession #
Q80TS7[Other Products]
Molecular Weight
76,407 Da
NCBI Official Full Name
dendrin
NCBI Official Synonym Full Names
dendrin
NCBI Official Symbol
Ddn??[Similar Products]
NCBI Official Synonym Symbols
Gm748
??[Similar Products]
NCBI Protein Information
dendrin
UniProt Protein Name
Dendrin
UniProt Gene Name
Ddn??[Similar Products]
UniProt Synonym Gene Names
Gm748; Kiaa0749??[Similar Products]
UniProt Comments for Ddn
Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein.
Research Articles on Ddn
1. ablation of the podocyte death-promoting protein dendrin delays onset of end-stage kidney disease, thereby expanding the life span of mice lacking the adapter protein CD2AP. Ablation of dendrin delays onset and severity of proteinuria and podocyte loss.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
