Full Product Name
Anti-TRP1 Rabbit pAb
Product Gene Name
anti-TRP1 antibody
[Similar Products]
Product Synonym Gene Name
CAS2; CATB; GP75; OCA3; TRP1; TYRP; TYRP1; TYRRP[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P17643
Specificity
TRP1 Antibody detects endogenous levels of total TRP1
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human TRP1
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-TRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TRP1 antibody
Oxidation of 5, 6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5, 6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
Applications Tested/Suitable for anti-TRP1 antibody
Western Blot (WB), Immunhistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-TRP1 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IP: 1:50
Western Blot (WB) of anti-TRP1 antibody
Western blot analysis of TRP1 expression in Human melanoma lysate.
NCBI/Uniprot data below describe general gene information for TRP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000541.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000550.2
[Other Products]
UniProt Primary Accession #
P17643
[Other Products]
UniProt Secondary Accession #
P78468; P78469; Q13721; Q15679[Other Products]
UniProt Related Accession #
P17643[Other Products]
NCBI Official Full Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
NCBI Official Synonym Full Names
tyrosinase related protein 1
NCBI Official Symbol
TYRP1??[Similar Products]
NCBI Official Synonym Symbols
TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
??[Similar Products]
NCBI Protein Information
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Protein Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Synonym Protein Names
Catalase B; Glycoprotein 75
Protein Family
Telomere repeat-binding protein
UniProt Gene Name
TYRP1??[Similar Products]
UniProt Synonym Gene Names
; TRP-1; TRP1??[Similar Products]
NCBI Summary for TRP1
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
UniProt Comments for TRP1
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu2+ ions (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin ().
Research Articles on TRP1
1. The rs387907171 SNP in TYRP1 exhibits strong allele frequency differences among islands in Northern Island Melanesia. Its absence from Bougainville, as well as the weak association with decreased hair color, indicates that additional alleles contribute to the blondism phenotype.
Precautions
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Disclaimer
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