RP11-3L8.1, CAS2, CATB, GP75, TRP, TYRP, b-PROTEIN

For Research Use Only. Not for use in diagnostic procedures.

Baculovirus-Insect Cells

> 96 % as determined by SDS-PAGE

Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly

Samples are stable for up to twelve months from date of receipt at -70 degree C

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of TRP1 / TYRP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Background: Tyrosinase-related protein 1, also known as TYRP1 or TRP1, is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5, 6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5, 6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.

Description: A DNA sequence encoding the human TYRP1 (P17643) extracellular domain (Met 1- Arg 471) was fused with a polyhistidine tag at the C-terminus.

The secreted recombinant human TYRP1 comprises 458 amino acids and has a predicted molecular mass of 52 kDa. The apparent molecular mass of rh TRP1 is approximately 55 kDa in SDS-PAGE under reducing conditions.

60,724 Da

tyrosinase related protein 1

5,6-dihydroxyindole-2-carboxylic acid oxidase

5,6-dihydroxyindole-2-carboxylic acid oxidase

CAS2; TYRP; TYRRP; DHICA oxidase; TRP; TRP-1; TRP1??[Similar Products]

This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]

TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family.

Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.18.-; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 9p23

Cellular Component: endosome membrane; melanosome; melanosome membrane

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: positive regulation of melanin biosynthetic process

Disease: Albinism, Oculocutaneous, Type Iii; Skin/hair/eye Pigmentation, Variation In, 11

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