TYRP1 Human; Tyrosinase Related Protein 1; Tyrosinase-Related Protein 1; Melanoma Antigen Gp75; Glycoprotein 75; DHICA Oxidase; Catalase B; CAS2; TRP1; TYRP; TRP; 5;6-Dihydroxyindole-2-Carboxylic Acid Oxidase; EC 1.14.18.1; EC 1.14.18.-; EC 1.14.18; B-PROTEIN; TRP-1; TYRRP; CATB; GP75; OCA3; 5;6-dihydroxyindole-2-carboxylic acid oxidase; Tyrosinase Related Protein 1 Human Recombinant

For Research Use Only. Not for use in diagnostic procedures.

Sf9, Baculovirus cells

Greater than 85.0% as determined by SDS-PAGE.

Sterile filtered colorless solution.
TYRP1 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Small volumes of TYRP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: TYRP1 Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 462 amino acids (25-477a.a) and having a molecular mass of 52.5kDa. (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). TYRP1 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Introduction: TYRP1, also known as 5, 6-dihydroxyindole-2-carboxylic acid oxidase, is a melanosomal enzyme which is a member of the tyrosinase family and takes a significant part in the melanin biosynthetic pathway. TYRP1 is a melanocyte-specific gene which is involved in eumelanin synthesis. Furthermore, TYRP1 is implicated in the oxidation of 5, 6-dihydroxyindole-2-carboxylic acid-DHICA into indole-5, 6-quinone-2-carboxylic acid. TYRP1 is regulated by the microphthalmia-associated transcription factor-MITF.

RECOMBINANT & NATURAL PROTEINS

60,724 Da

tyrosinase related protein 1

5,6-dihydroxyindole-2-carboxylic acid oxidase

5,6-dihydroxyindole-2-carboxylic acid oxidase

CAS2; TYRP; TYRRP; DHICA oxidase; TRP; TRP-1; TRP1??[Similar Products]

This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]

TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family.

Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.18.-; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 9p23

Cellular Component: endosome membrane; melanosome; melanosome membrane

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: positive regulation of melanin biosynthetic process

Disease: Albinism, Oculocutaneous, Type Iii; Skin/hair/eye Pigmentation, Variation In, 11

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