Full Product Name
TYRP1 Antibody
Product Synonym Names
TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
Product Gene Name
anti-TYRP1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P17643
Specificity
The antibody detects endogenous levels of total TYRP1 protein.
Purity/Purification
Antigen affinity purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.7mg/ml (lot specific)
Immunogen
Synthetic peptide of human TYRP1
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-TYRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TYRP1 antibody
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
Product Categories/Family for anti-TYRP1 antibody
Total protein Ab
Applications Tested/Suitable for anti-TYRP1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-TYRP1 antibody
Immunohistochemistry: 1: 20-100
Immunohistochemistry (IHC) of anti-TYRP1 antibody
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TYRP1 Antibody at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200)
Immunohistochemistry (IHC) of anti-TYRP1 antibody
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using TYRP1 Antibody at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200)
NCBI/Uniprot data below describe general gene information for TYRP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000541.1
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NCBI GenBank Nucleotide #
NM_000550.2
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UniProt Primary Accession #
P17643
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UniProt Secondary Accession #
P78468; P78469; Q13721; Q15679[Other Products]
UniProt Related Accession #
P17643[Other Products]
Molecular Weight
60,724 Da
NCBI Official Full Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
NCBI Official Synonym Full Names
tyrosinase related protein 1
NCBI Official Symbol
TYRP1??[Similar Products]
NCBI Official Synonym Symbols
TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
??[Similar Products]
NCBI Protein Information
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Protein Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Synonym Protein Names
Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1
Protein Family
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Gene Name
TYRP1??[Similar Products]
UniProt Synonym Gene Names
CAS2; TYRP; TYRRP; DHICA oxidase; TRP; TRP-1; TRP1??[Similar Products]
UniProt Entry Name
TYRP1_HUMAN
NCBI Summary for TYRP1
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
UniProt Comments for TYRP1
TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family.
Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.18.-; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 9p23
Cellular Component: endosome membrane; melanosome; melanosome membrane
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: positive regulation of melanin biosynthetic process
Disease: Albinism, Oculocutaneous, Type Iii; Skin/hair/eye Pigmentation, Variation In, 11
Research Articles on TYRP1
1. Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma.
Precautions
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