Product Name
SLC26A1/SAT-1, Polyclonal Antibody
Full Product Name
Goat anti-SLC26A1/SAT-1 Antibody
Product Synonym Names
SLC26A1; solute carrier family 26 (sulfate transporter), member 1; EDM4; SAT-1; SAT1; sulfate anion tranporter AT1; sulfate anion transporter 1; sulfate/anion transporter SAT-1 protein; SLC26A1 antibody; solute carrier family 26 (sulfate transporter); member 1 antibody; EDM4 antibody; SAT-1 antibody; SAT1 antibody; sulfate anion tranporter AT1 antibody; sulfate anion transporter 1 antibody; sulfate/anion transporter SAT-1 protein antibody; SLC26A1 / SAT-1
Product Gene Name
anti-SLC26A1 antibody
[Similar Products]
Product Synonym Gene Name
SAT-1[Similar Products]
Antibody/Peptide Pairs
SLC26A1 / SAT-1 peptide (MBS428176) is used for blocking the activity of SLC26A1/SAT-1 antibody (MBS423450)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
QTARARHREL EATD
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-QTARARHRELEATD, from the C Terminus of the protein sequence according to NP_071325.2; NP_602297.1.
Note
This antibody is expected to recognize reported isoform a (NP_071325.2) only. Reported variants represent identical protein: NP_998778.1, NP_071325.2
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-SLC26A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SLC26A1 antibody
Peptide ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-SLC26A1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Immunohistochemistry: In paraffin embedded Human Kidney shows strong basal membrane staining in convoluted tubules. Recommended concentration, 2-4ug/ml.
Immunohistochemistry (IHC) of anti-SLC26A1 antibody
(2ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
NCBI/Uniprot data below describe general gene information for SLC26A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071325.2
[Other Products]
NCBI Related Accession #
Manufactured in an ISO 9001:2008 Certified Laboratory.NP_602297.1[Other Products]
NCBI GenBank Nucleotide #
NM_022042.3
[Other Products]
UniProt Secondary Accession #
Q7Z5R3; Q96BK0; A8K9N2[Other Products]
UniProt Related Accession #
Q9H2B4[Other Products]
Molecular Weight
24,962 Da
NCBI Official Full Name
sulfate anion transporter 1 isoform a
NCBI Official Synonym Full Names
solute carrier family 26 member 1
NCBI Official Symbol
SLC26A1??[Similar Products]
NCBI Official Synonym Symbols
EDM4; SAT1; SAT-1
??[Similar Products]
NCBI Protein Information
sulfate anion transporter 1
UniProt Protein Name
Sulfate anion transporter 1
UniProt Synonym Protein Names
Solute carrier family 26 member 1
Protein Family
Sulfate anion transporter
UniProt Gene Name
SLC26A1??[Similar Products]
UniProt Synonym Gene Names
SAT1; SAT-1??[Similar Products]
UniProt Entry Name
S26A1_HUMAN
NCBI Summary for SLC26A1
This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC26A1
SLC26A1: High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; oxalate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; sulfate transmembrane transporter activity
Biological Process: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; bicarbonate transport; chloride transport; ion transport; oxalate transport; regulation of intracellular pH; regulation of membrane potential; sulfate transport
Research Articles on SLC26A1
1. Screened the SLC26A1 gene in a cohort of 13 individuals with recurrent calcium oxalate urolithiasis, which is the commonest type. DNA sequence analyses showed missense mutations in seven patients.
Precautions
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Disclaimer
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