Dihydropyrimidinase; DHP; DHPase; Dihydropyrimidine amidohydrolase; Hydantoinase

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Recognizes endogenous levels of Dihydropyrimidinase protein.

The antibody was purified by immunogen affinity chromatography.

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Small volumes of anti-DPYS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal antibody to Dihydropyrimidinase

Western Blot (WB)

WB: 1/500 - 1/2000

Western blot analysis of Dihydropyrimidinase expression in HEK293T (A), mouse liver (B), mouse brain (C), rat kidney (D) whole cell lysates.

56,630 Da

dihydropyrimidinase

dihydropyrimidinase

Dihydropyrimidinase

DHP; DHPase??[Similar Products]

DPYS_HUMAN

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Protein type: Other Amino Acids Metabolism - beta-alanine; EC 3.5.2.2; Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: cytosol

Molecular Function: amino acid binding; dihydropyrimidinase activity; phosphoprotein binding; thymine binding; uracil binding; zinc ion binding

Biological Process: beta-alanine metabolic process; protein homotetramerization; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymine catabolic process; uracil catabolic process

Disease: Dihydropyrimidinase Deficiency

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