Full Product Name
Anti-DPYS Antibody
Product Gene Name
anti-DPYS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human DPYS
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-DPYS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DPYS antibody
Dihydropyrimidinase catalyzes the conversion of 5, 6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript.
Applications Tested/Suitable for anti-DPYS antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DPYS antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for DPYS. It may not necessarily be applicable to this product.
NCBI Accession #
AKI71101.1
[Other Products]
UniProt Related Accession #
Q14117[Other Products]
Molecular Weight
56,630 Da
NCBI Official Full Name
DPYS, partial
NCBI Official Synonym Full Names
dihydropyrimidinase
NCBI Official Symbol
DPYS??[Similar Products]
NCBI Official Synonym Symbols
DHP; DHPase
??[Similar Products]
NCBI Protein Information
dihydropyrimidinase
UniProt Protein Name
Dihydropyrimidinase
UniProt Synonym Protein Names
Dihydropyrimidine amidohydrolase; Hydantoinase
UniProt Gene Name
DPYS??[Similar Products]
UniProt Synonym Gene Names
DHP; DHPase??[Similar Products]
NCBI Summary for DPYS
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
UniProt Comments for DPYS
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
Research Articles on DPYS
1. A in intron 8 and a previously described missense mutation c.1001A>G (p.Q334R) in exon 6.">Two unrelated pediatric DPYS deficiency cases are being described as compound heterozygotes for a novel intronic mutation c.1443+5G>A in intron 8 and a previously described missense mutation c.1001A>G (p.Q334R) in exon 6.
Precautions
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Disclaimer
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