Product Name
YARS, cDNA Clone
Full Product Name
YARS cDNA Clone
Product Gene Name
YARS cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca gacttcttaa aggcagggtg tgaggtaaca attctgtttg cggacctcca cgcatacctg gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat gtgaagaaaa aactgaagaa ggccttctgt gagccaggaa atgtggagaa caatggggtt ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc tacccagatc cctcaaagca gaagccaatg gccaaaggcc ctgccaagaa ttcagaacca gaggaggtca tcccatcccg gctggatatc cgtgtgggga aaatcatcac tgtggagaag cacccagatg cagacagcct gtatgtagag aagattgacg tgggggaagc tgaaccacgg actgtggtga gcggcctggt acagttcgtg cccaaggagg aactgcagga caggctggta gtggtgctgt gcaacctgaa accccagaag atgagaggag tcgagtccca aggcatgctt ctgtgtgctt ctatagaagg gataaaccgc caggttgaac ctctggaccc tccggcaggc tctgctcctg gtgagcacgt gtttgtgaag ggctatgaaa agggccaacc agatgaggag ctcaagccca agaagaaagt cttcgagaag ttgcaggctg acttcaaaat ttctgaggag tgcatcgcac agtggaagca aaccaacttc atgaccaagc tgggctccat ttcctgtaaa tcgctgaaag gggggaacat tagctag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of YARS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for YARS. It may not necessarily be applicable to this product.
NCBI Accession #
BC001933
[Other Products]
UniProt Secondary Accession #
O43276; Q53EN1; B3KWK4; D3DPQ4[Other Products]
UniProt Related Accession #
P54577[Other Products]
Molecular Weight
59,143 Da
NCBI Official Full Name
Homo sapiens tyrosyl-tRNA synthetase, mRNA
NCBI Official Synonym Full Names
tyrosyl-tRNA synthetase
NCBI Official Symbol
YARS??[Similar Products]
NCBI Official Synonym Symbols
YRS; YTS; TYRRS; CMTDIC
??[Similar Products]
NCBI Protein Information
tyrosine--tRNA ligase, cytoplasmic
UniProt Protein Name
Tyrosine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Tyrosyl-tRNA synthetase; TyrRS
Protein Family
Tyrosine--tRNA ligase
UniProt Gene Name
YARS??[Similar Products]
UniProt Synonym Gene Names
TyrRS??[Similar Products]
UniProt Entry Name
SYYC_HUMAN
NCBI Summary for YARS
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
UniProt Comments for YARS
YARS: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC). CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein type: Ligase; EC 6.1.1.1
Chromosomal Location of Human Ortholog: 1p35.1
Cellular Component: cytoplasm; cytosol; extracellular space; nucleus
Molecular Function: interleukin-8 receptor binding; protein binding; tyrosine-tRNA ligase activity; valine-tRNA ligase activity
Biological Process: apoptosis; tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation
Disease: Charcot-marie-tooth Disease, Dominant Intermediate C
Research Articles on YARS
1. Data show that the internal deletion of tyrosyl-tRNA synthetase TyrRSDeltaE2-4 splice variants (SVs) gave an alternative, neomorphic dimer interface 'orthogonal' to that of native TyrRS.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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