Product Name
DPYS, Polyclonal Antibody
Popular Item
Full Product Name
DPYS Antibody
Product Synonym Names
Dihydropyrimidinase; Dihydropyrimidine amidohydrolase; Hydantoinase; DPYS
Product Gene Name
anti-DPYS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14117
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Immunogen
Recombinant human Dihydropyrimidinase protein (C-270AA)
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-133521
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-DPYS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DPYS antibody
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
Applications Tested/Suitable for anti-DPYS antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of anti-DPYS antibody
Western blot
All lanes: DPYS antibody at 1.34ug/ml+Mouse liver tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 57kDa
Observed band size: 57kDa
Immunohistochemistry (IHC) of anti-DPYS antibody
Immunohistochemistry of paraffin-embedded human liver tissue using MBS7045295 at dilution 1:100
Immunohistochemistry (IHC) of anti-DPYS antibody
Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7045295 at dilution 1:100
NCBI/Uniprot data below describe general gene information for DPYS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001376.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001385.2
[Other Products]
UniProt Primary Accession #
Q14117
[Other Products]
UniProt Related Accession #
Q14117[Other Products]
Molecular Weight
56,630 Da
NCBI Official Full Name
dihydropyrimidinase
NCBI Official Synonym Full Names
dihydropyrimidinase
NCBI Official Symbol
DPYS??[Similar Products]
NCBI Official Synonym Symbols
DHP; DHPase
??[Similar Products]
NCBI Protein Information
dihydropyrimidinase
UniProt Protein Name
Dihydropyrimidinase
UniProt Synonym Protein Names
Dihydropyrimidine amidohydrolase; Hydantoinase
UniProt Gene Name
DPYS??[Similar Products]
UniProt Synonym Gene Names
DHP; DHPase??[Similar Products]
UniProt Entry Name
DPYS_HUMAN
NCBI Summary for DPYS
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
UniProt Comments for DPYS
DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Protein type: Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - beta-alanine; Hydrolase; EC 3.5.2.2; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: cytosol
Molecular Function: dihydropyrimidinase activity
Biological Process: protein homotetramerization; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymine catabolic process; uracil catabolic process
Disease: Dihydropyrimidinase Deficiency
Research Articles on DPYS
1. Stepwise Cox regression modelling suggested that the methylation of genes HSPB1, CCND2 and DPYS contributed objective prognostic information to Gleason score and PSA with respect to prostate cancer-related death.
Precautions
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Disclaimer
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