Full Product Name
DPYS antibody
Product Synonym Names
DHP; DHPase
Product Gene Name
anti-DPYS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14117
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous level of total DPYS antibody.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human DPYS.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-DPYS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DPYS antibody
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
Product Categories/Family for anti-DPYS antibody
Total protein Ab
Applications Tested/Suitable for anti-DPYS antibody
Western Blot (WB)
Application Notes for anti-DPYS antibody
Western blotting: 1:500 - 1:2000
Western Blot (WB) of anti-DPYS antibody
Western blot analysis of extracts of various cell lines, using DPYS antibody.
NCBI/Uniprot data below describe general gene information for DPYS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001376.1
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NCBI GenBank Nucleotide #
NM_001385.2
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UniProt Primary Accession #
Q14117
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UniProt Related Accession #
Q14117[Other Products]
Molecular Weight
56,630 Da
NCBI Official Full Name
dihydropyrimidinase
NCBI Official Synonym Full Names
dihydropyrimidinase
NCBI Official Symbol
DPYS??[Similar Products]
NCBI Official Synonym Symbols
DHP; DHPase
??[Similar Products]
NCBI Protein Information
dihydropyrimidinase
UniProt Protein Name
Dihydropyrimidinase
UniProt Synonym Protein Names
Dihydropyrimidine amidohydrolase; Hydantoinase
UniProt Gene Name
DPYS??[Similar Products]
UniProt Synonym Gene Names
DHP; DHPase??[Similar Products]
UniProt Entry Name
DPYS_HUMAN
NCBI Summary for DPYS
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
UniProt Comments for DPYS
DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Other Amino Acids Metabolism - beta-alanine; Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 3.5.2.2; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: cytosol
Molecular Function: thymine binding; amino acid binding; dihydropyrimidinase activity; uracil binding; zinc ion binding; phosphoprotein binding
Biological Process: beta-alanine metabolic process; pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; uracil catabolic process; thymine catabolic process; pyrimidine base catabolic process; protein homotetramerization
Disease: Dihydropyrimidinase Deficiency
Research Articles on DPYS
1. Stepwise Cox regression modelling suggested that the methylation of genes HSPB1, CCND2 and DPYS contributed objective prognostic information to Gleason score and PSA with respect to prostate cancer-related death.
Precautions
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Disclaimer
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