Dihydropyrimidinase; DHP; DHPase; Dihydropyrimidine amidohydrolase; Hydantoinase; Dpys

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This mouse Dpys antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 470-501 amino acids from the C-terminal region of mouse Dpys.

Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-Dpys antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate (By similarity).

Crown Antibodies

Western Blot (WB), ELISA (EIA)

WB~~1:1000

Western blot analysis of lysate from mouse liver tissue, using mouse Dpys Antibody (C-term). MBS9208489 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.

56725

dihydropyrimidinase

dihydropyrimidinase

Dihydropyrimidinase

DHP; DHPase??[Similar Products]

DPYS_MOUSE

DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Protein type: EC 3.5.2.2; Other Amino Acids Metabolism - beta-alanine; Hydrolase; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis

Cellular Component: cytoplasm; cytosol

Molecular Function: thymine binding; amino acid binding; dihydropyrimidinase activity; hydrolase activity; zinc ion binding; uracil binding; metal ion binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; phosphoprotein binding

Biological Process: uracil metabolic process; beta-alanine metabolic process; uracil catabolic process; thymine catabolic process; protein homooligomerization; pyrimidine base catabolic process; protein homotetramerization

Fukada M.,et al.J. Biol. Chem. 275:37957-37965(2000).
Chang C.J.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).

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