Product Name
beta I Tubulin (TUBB1), Monoclonal Antibody
Full Product Name
Anti-beta I Tubulin Mouse mAb
Product Synonym Names
2810484G07Rik; Beta tubulin 1, class VI; Class VI beta tubulin; dJ543J19.4; M (beta)1; TBB1_HUMAN; TUBB1; Tubulin beta 1 class VI; Tubulin beta-1 chain; Tubulin, beta 1; tubulin, beta1
Product Gene Name
anti-TUBB1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H4B7
Species Reactivity
Human, Rat
Form/Format
Purified antibody in PBS with 0.05% sodium azide.
Immunogen
Purified recombinant fragment of human TUBB1 (AA: 33-166) expressed in E Coli.
Sequence Similarities
Belongs to the tubulin family.
Subunit Structure
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with RANBP10.
Subcellular Location
Cytoplasm; Cytoskeleton
Other Notes
Small volumes of anti-TUBB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TUBB1 antibody
Entrez Summary: This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.
UniPort Summary Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Applications Tested/Suitable for anti-TUBB1 antibody
Western Blot (WB)
Western Blot (WB) of anti-TUBB1 antibody
Western blot detection of beta I Tubulin in Jurkat, A549, MCF7, C6 and Hela cell lysates using beta I Tubulin mouse mAb (1:5000 diluted).Predicted band size:50KDa.Observed band size:50KDa.
NCBI/Uniprot data below describe general gene information for TUBB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_110400.1
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NCBI GenBank Nucleotide #
NM_030773.3
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UniProt Primary Accession #
Q9H4B7
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UniProt Related Accession #
Q9H4B7[Other Products]
NCBI Official Full Name
tubulin beta-1 chain
NCBI Official Synonym Full Names
tubulin beta 1 class VI
NCBI Official Symbol
TUBB1??[Similar Products]
NCBI Protein Information
tubulin beta-1 chain
UniProt Protein Name
Tubulin beta-1 chain
UniProt Gene Name
TUBB1??[Similar Products]
NCBI Summary for TUBB1
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010]
UniProt Comments for TUBB1
TUBB1: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Interacts with RANBP10. Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins. Belongs to the tubulin family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20q13.32
Cellular Component: cytoplasm
Disease: Macrothrombocytopenia, Autosomal Dominant, Tubb1-related
Research Articles on TUBB1
1. Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect.
Precautions
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