Product Name
Beta-tubulin (TUBB1), Polyclonal Antibody
Full Product Name
Anti-Beta-tubulin Antibody
Product Synonym Names
TUBB1; Tubulin beta-1 chain; TUBB2A; TUBB2; Tubulin beta-2A chain; TUBB2B; Tubulin beta-2B chain; TUBB4B; TUBB2C; Tubulin beta-4B chain; Tubulin beta-2 chain; Tubulin beta-2C chain; TUBB3; TUBB4; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III; TUBB4A; TUBB4; TUBB5; Tubulin beta-4A chain; Tubulin 5 beta; Tubulin beta-4 chain; TUBB; TUBB5; OK/SW-cl.56; Tubulin beta chain; Tubulin beta-5 chain; TUBB6; Tubulin beta-6 chain; TUBB8; Tubulin beta-8 chain
Product Gene Name
anti-TUBB1 antibody
[Similar Products]
Product Synonym Gene Name
TUBB2A; TUBB2B; TUBB4B; TUBB[Similar Products]
Antibody/Peptide Pairs
Beta-tubulin peptide (MBS8200736) is used for blocking the activity of Beta-tubulin antibody (MBS8233417)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H4B7
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Beta-tubulin protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Beta-tubulin. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-TUBB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TUBB1 antibody
Rabbit polyclonal antibody to Beta-tubulin
Applications Tested/Suitable for anti-TUBB1 antibody
Western Blot (WB)
Application Notes for anti-TUBB1 antibody
WB (1/500 - 1/1000)
Western Blot (WB) of anti-TUBB1 antibody
Western blot analysis of Beta-tubulin expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for TUBB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_110400.1
[Other Products]
NCBI GenBank Nucleotide #
NM_030773.3
[Other Products]
UniProt Primary Accession #
Q9H4B7
[Other Products]
UniProt Secondary Accession #
Q13885; Q9BVA1; P68371; Q13509; Q99867; P04350; P07437; Q9BUF5; Q3ZCM7[Other Products]
UniProt Related Accession #
Q9H4B7[Other Products]
Molecular Weight
50,327 Da
NCBI Official Full Name
tubulin beta-1 chain
NCBI Official Synonym Full Names
tubulin, beta 1 class VI
NCBI Official Symbol
TUBB1??[Similar Products]
NCBI Protein Information
tubulin beta-1 chain
UniProt Protein Name
Tubulin beta-1 chain
UniProt Gene Name
TUBB1??[Similar Products]
UniProt Entry Name
TBB1_HUMAN
NCBI Summary for TUBB1
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010]
UniProt Comments for TUBB1
TUBB1: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Interacts with RANBP10. Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins. Belongs to the tubulin family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 20q13.32
Cellular Component: microtubule; cytoplasm
Molecular Function: GTPase activity; GTP binding; structural constituent of cytoskeleton
Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; spindle assembly; transmembrane transport
Disease: Macrothrombocytopenia, Autosomal Dominant, Tubb1-related
Research Articles on TUBB1
1. Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer.
Precautions
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Disclaimer
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