Human Homeobox protein Nkx-6.1 (NKX6-1) ELISA kit; NKX6.1; NKX6A; NK homeo box; family 6; member A; NK homeobox; family 6; A; NK6 transcription factor homolog A; NK6 transcription factor related; locus 1; NK6 homeobox 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of NKX6-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9326386 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the NK6 homeobox 1 (NKX6-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NKX6-1. The ELISA analytical biochemical technique of the MBS9326386 kit is based on NKX6-1 antibody-NKX6-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NKX6-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NKX6-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

37,849 Da

NK6 homeobox 1

homeobox protein Nkx-6.1; NK homeobox, family 6, A; homeobox protein NK-6 homolog A; NK homeo box, family 6, member A; NK6 transcription factor homolog A; NK6 transcription factor related, locus 1

Homeobox protein Nkx-6.1

NKX6A??[Similar Products]

NKX61_HUMAN

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]

NKX6-1: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.

Protein type: DNA-binding; Cell development/differentiation; Transcription factor

Chromosomal Location of Human Ortholog: 4q21.33

Cellular Component: nucleoplasm

Molecular Function: chromatin binding

Biological Process: response to drug; transcription from RNA polymerase II promoter; response to nicotine; smoothened signaling pathway; positive regulation of insulin secretion; positive regulation of glial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of axon extension; endocrine pancreas development; negative regulation of glial cell differentiation; cell proliferation; organ morphogenesis; detection of glucose; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; pancreas development; oligodendrocyte differentiation; regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of neuron differentiation

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