Full Product Name
SMARCAL1 Antibody
Product Gene Name
anti-SMARCAL1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NZC9
Other Notes
Small volumes of anti-SMARCAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SMARCAL1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001120679.1
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NCBI GenBank Nucleotide #
NM_001127207.1
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UniProt Primary Accession #
Q9NZC9
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UniProt Secondary Accession #
Q53R00; Q96AY1; Q9NXQ5; Q9UFH3; Q9UI93; A6NEH0[Other Products]
UniProt Related Accession #
Q9NZC9[Other Products]
Molecular Weight
105,938 Da
NCBI Official Full Name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
NCBI Official Synonym Full Names
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1
NCBI Official Symbol
SMARCAL1??[Similar Products]
NCBI Official Synonym Symbols
HARP; HHARP
??[Similar Products]
NCBI Protein Information
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
UniProt Protein Name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
UniProt Synonym Protein Names
HepA-related protein; hHARP; Sucrose nonfermenting protein 2-like 1
UniProt Gene Name
SMARCAL1??[Similar Products]
UniProt Synonym Gene Names
HARP; hHARP??[Similar Products]
NCBI Summary for SMARCAL1
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for SMARCAL1
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.
Research Articles on SMARCAL1
1. A large number of SNF2 family, DNA and ATP-dependent motor proteins are needed during transcription, DNA replication, and DNA repair to manipulate protein-DNA interactions and change DNA structure. SMARCAL1, ZRANB3, and HLTF are three related members of this family with specialized functions that maintain genome stability during DNA replication. [review]
Precautions
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Disclaimer
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