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SMARCAL1, siRNA

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產(chǎn)品名稱: SMARCAL1, siRNA
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SMARCAL1, siRNA


SMARCAL1, siRNA  的詳細(xì)介紹
Product Name

SMARCAL1, siRNA

Full Product Name

SMARCAL1 siRNA (Mouse)

Product Synonym Names
HARP; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; HepA-related protein; mharp; Sucrose nonfermenting protein 2-like 1
Product Gene Name

SMARCAL1 sirna

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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3D Structure
ModBase 3D Structure for Q8BJL0
Host
Synthetic
Species Reactivity
Mouse
Specificity
SMARCAL1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse SMARCAL1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Other Notes
Small volumes of SMARCAL1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
SMARCAL1 sirna
siRNA to inhibit SMARCAL1 expression using RNA interference
Applications Tested/Suitable for SMARCAL1 sirna
RNA Interference (RNAi)
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NCBI/Uniprot data below describe general gene information for SMARCAL1. It may not necessarily be applicable to this product.
NCBI GI #
229577278
NCBI GeneID
54380
NCBI Accession #
NP_061287.2 [Other Products]
NCBI GenBank Nucleotide #
NM_018817.2 [Other Products]
UniProt Primary Accession #
Q8BJL0 [Other Products]
UniProt Secondary Accession #
Q3TEQ9; Q3U4W0; Q3V3A8; Q8BVK7; Q8BXW4; Q8K309; Q9EQK8; Q9QYC4[Other Products]
UniProt Related Accession #
Q8BJL0[Other Products]
Molecular Weight
44,190 Da
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NCBI Official Full Name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
NCBI Official Synonym Full Names
SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
NCBI Official Symbol
Smarcal1??[Similar Products]
NCBI Official Synonym Symbols
Mharp; AI851716; 6030401P21Rik
??[Similar Products]
NCBI Protein Information
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
UniProt Protein Name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
UniProt Synonym Protein Names
HepA-related protein; mharp; Sucrose nonfermenting protein 2-like 1
UniProt Gene Name
Smarcal1??[Similar Products]
UniProt Synonym Gene Names
Harp; mharp??[Similar Products]
UniProt Entry Name
SMAL1_MOUSE
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UniProt Comments for SMARCAL1
SMARCAL1: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. Defects in SMARCAL1 are a cause of Schimke immuno-osseous dysplasia (SIOD). SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.

Protein type: EC 3.6.4.-; Helicase; EC 3.6.1.-

Cellular Component: nucleoplasm; DNA replication factor A complex; nucleus

Molecular Function: DNA-dependent ATPase activity; DNA binding; hydrolase activity; nucleotide binding; helicase activity; ATP binding

Biological Process: regulation of transcription from RNA polymerase II promoter; DNA strand renaturation; chromatin modification; DNA repair; response to DNA damage stimulus; DNA metabolic process; replication fork processing
Research Articles on SMARCAL1
1. the role of SMARCAL1 in the pathogenesis of Schimke immuno-osseous dysplasia
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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