Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel

For Research Use Only. Not for use in diagnostic procedures.

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Kcne1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

14,699 Da

potassium voltage-gated channel, Isk-related family, member 1

potassium voltage-gated channel subfamily E member 1; mink; minimal potassium channel; delayed rectifier potassium channel subunit IsK; potassium (K+) channel protein, slowly activating (Isk); potassium voltage-gated channel Shaw-related subfamily member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; IKs producing slow voltage-gated potassium channel subunit beta Mink

Potassium voltage-gated channel subfamily E member 1

KCNE1_RAT

beta subunit of the voltage-gated potassium channel complex; involved in modulating channel kinetics [RGD, Feb 2006]

KCNE1: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Associates with KCNQ1/KVLQT1 and KCNH2/HERG. Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral; Channel, potassium

Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; cell surface; lysosome; endoplasmic reticulum; apical plasma membrane; plasma membrane; Z disc

Molecular Function: voltage-gated potassium channel activity; protein binding; potassium channel regulator activity; telethonin binding; protein heterodimerization activity; delayed rectifier potassium channel activity

Biological Process: protein amino acid O-linked glycosylation; heart contraction; epithelial cell maturation; male gonad development; protein amino acid N-linked glycosylation

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