Product Name
Anosmin (KAL1), Blocking Peptide
Full Product Name
Anosmin Blocking Peptide
Product Synonym Names
ADMLX; KAL; KALIG1; Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein
Product Gene Name
KAL1 blocking peptide
[Similar Products]
Anosmin peptide (MBS823065) is used for blocking the activity of Anosmin antibody (MBS821684)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P23352
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of KAL1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
KAL1 blocking peptide
The peptide is used to block Anti-Anosmin Antibody reactivity.
Applications Tested/Suitable for KAL1 blocking peptide
Blocking (BL)
Application Notes for KAL1 blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for KAL1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000207.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000216.2
[Other Products]
UniProt Primary Accession #
P23352
[Other Products]
UniProt Secondary Accession #
B2RPF8[Other Products]
UniProt Related Accession #
P23352[Other Products]
Molecular Weight
76,112 Da
NCBI Official Full Name
anosmin-1
NCBI Official Synonym Full Names
Kallmann syndrome 1 sequence
NCBI Official Symbol
KAL1??[Similar Products]
NCBI Official Synonym Symbols
HH1; HHA; KAL; KMS; ADMLX; WFDC19; KALIG-1
??[Similar Products]
NCBI Protein Information
anosmin-1; kallmann syndrome protein; adhesion molecule-like X-linked; Kallmann syndrome interval gene 1; WAP four-disulfide core domain 19; Kallmann syndrome-1 sequence (anosmin-1)
UniProt Protein Name
Anosmin-1
UniProt Synonym Protein Names
Adhesion molecule-like X-linked; Kallmann syndrome protein
UniProt Gene Name
KAL1??[Similar Products]
UniProt Synonym Gene Names
ADMLX; KAL; KALIG1??[Similar Products]
UniProt Entry Name
KALM_HUMAN
NCBI Summary for KAL1
Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]
UniProt Comments for KAL1
KAL1: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex. Chemoattractant for fetal olfactory epithelial cells. Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
Protein type: Extracellular matrix; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xp22.32
Cellular Component: proteinaceous extracellular matrix; extracellular space; plasma membrane
Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; extracellular matrix structural constituent
Biological Process: axon guidance; cell motility; chemotaxis; cell adhesion
Disease: Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Research Articles on KAL1
1. anosmin-1 has been identified in other pathological scenarios both within (multiple sclerosis) and outside (cancer, atopic dermatitis) the central nerve system.
Precautions
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Disclaimer
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