Human Transcription termination factor; mitochondrial (MTERF) ELISA kit; MGC131634; transcription termination factor; mitochondrial; mitochondrial transcription termination factor

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of MTERF elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9339351 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the mitochondrial transcription termination factor (MTERF) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MTERF. The ELISA analytical biochemical technique of the MBS9339351 kit is based on MTERF antibody-MTERF antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MTERF antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MTERF. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

45,778 Da

mitochondrial transcription termination factor 1

transcription termination factor, mitochondrial

Transcription termination factor 1, mitochondrial

MTERF; mTERF; mTERF1??[Similar Products]

MTEF1_HUMAN

This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]

MTERF: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity. Belongs to the mTERF family.

Chromosomal Location of Human Ortholog: 7q21.2

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: protein binding; double-stranded DNA binding

Biological Process: termination of mitochondrial transcription; mitochondrion organization and biogenesis; regulation of transcription, DNA-dependent; organelle organization and biogenesis; gene expression; transcription termination; DNA geometric change; transcription from mitochondrial promoter

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