Glutamate receptor ionotropic; kainate 3; GluK3; Excitatory amino acid receptor 5; EAA5; Glutamate receptor 7; GluR-7; GluR7; GRIK3; GLUR7

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This GRIK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human GRIK3.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-GRIK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Glutamate receptors are the predominant excitatory
neurotransmitter receptors in the mammalian brain and are activated
in a variety of normal neurophysiologic processes. This gene
product belongs to the kainate family of glutamate receptors, which
are composed of four subunits and function as ligand-activated ion
channels. It is not certain if the subunit encoded by this gene is
subject to RNA editing as the other 2 family members (GRIK1 and
GRIK2). A Ser310Ala polymorphism has been associated with
schizophrenia, and there are conflicting reports of its association
with the pathogenesis of delirium tremens in alcoholics. [provided
by RefSeq].

Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

WB~~1:1000

GRIK3 Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the GRIK3 antibody detected the GRIK3 protein (arrow).

GRIK3 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GRIK3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

104037

glutamate receptor, ionotropic, kainate 3

glutamate receptor ionotropic, kainate 3

Glutamate receptor ionotropic, kainate 3

GLUR7; GluK3; EAA5; GluR-7; GluR7??[Similar Products]

GRIK3_HUMAN

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]

GluR7: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: presynaptic membrane; dendrite cytoplasm; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; axon; dendrite; plasma membrane; terminal button; perikaryon; cell junction

Molecular Function: adenylate cyclase inhibiting metabotropic glutamate receptor activity; kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; glutamate receptor activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; regulation of membrane potential; ionotropic glutamate receptor signaling pathway; glutamate signaling pathway; metabotropic glutamate receptor signaling pathway; negative regulation of synaptic transmission, glutamatergic; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Luciano, M., et al. Behav. Genet. 40(4):518-532(2010)
Kilic, G., et al. Psychiatry Res 175 (1-2), 43-46 (2010) :
Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)
Ahmad, Y., et al. World J. Biol. Psychiatry 10(4):330-333(2009)

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