Glutaredoxin-related protein 5 mitochondrial; C14orf87; GRX5; Glutaredoxin-related protein 5; mitochondrial Chromosome 14 open reading frame 87; FLB4739; GLRX 5; Glutaredoxin 5 homolog; Glutaredoxin related protein 5; Glutaredoxin5; GRX5; MGC14129; PRO1238.

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 85% by SDS-PAGE

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl

0.5 mg/ml (determined by Bradford assay) (lot specific)

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Small volumes of GLRX5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

GLRX5 is small redox enzymes of approximately one hundred amino-acid residues which uses glutathione as a cofactor. This protein is oxidized by substrates, and reduced non-enzymatically by glutathione. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Recombinant human GLRX5 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques

Redox Proteins

SDS-PAGE

18.8 kDa (177aa), confirmed by MALDI-TOF

glutaredoxin 5

glutaredoxin-related protein 5, mitochondrial

Glutaredoxin-related protein 5, mitochondrial

C14orf87??[Similar Products]

This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress ().

Holmgren A., et al. (1988) FEMS Microbiol. Rev. 4 (4): 271-297.; Holmgren A., et al. (1988) Biochem. Soc. Trans. 16 (2): 95-96.;

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