SLC25A38; solute carrier family 25, member 38; FLJ20551; FLJ22703; FLJ20551 antibody; FLJ22703 antibody; SLC25A38 antibody; solute carrier family 25; member 38 antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-SLC25A38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments in lysates of cell lines Jurkat and K562 gave no specific signal but low background (at antibody concentration up to 2ug/ml).

33,566 Da

solute carrier family 25 member 38

solute carrier family 25 member 38

Solute carrier family 25 member 38

S2538_HUMAN

This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia.[provided by RefSeq, Mar 2010]

SLC25A38: Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane. Defects in SLC25A38 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA). A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. Belongs to the mitochondrial carrier family. SLC25A38 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family; Mitochondrial

Chromosomal Location of Human Ortholog: 3p22.1

Cellular Component: integral to membrane; mitochondrial inner membrane

Molecular Function: structural constituent of ribosome; transporter activity

Biological Process: erythrocyte differentiation; heme biosynthetic process; translation; transport

Disease: Anemia, Sideroblastic, Pyridoxine-refractory, Autosomal Recessive

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