Product Name
SBDS, cDNA Clone
Product Synonym Names
CGI-97; SDS; SWDS
Product Gene Name
SBDS cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Nucleotide Sequence: ATGTCGATCT TCACCCCCAC CAACCAGATC CGCCTAACCA ATGTGGCCGT GGTACGGATG AAGCGTGCCG GGAAGCGCTT CGAAATCGCC TGCTACAAAA ACAAGGTCGT CGGCTGGCGG AGCGGCGTGG AAAAAGACCT CGATGAAGTT CTGCAGACCC ACTCAGTGTT TGTAAATGTT TCTAAAGGTC AGGTTGCCAA AAAGGAAGAT CTCATCAGTG CGTTTGGAAC AGATGACCAA ACTGAAATCT GTAAGCAGAT TTTGACTAAA GGAGAAGTTC AAGTATCAGA TAAAGAAAGA CACACACAAC TGGAGCAGAT GTTTAGGGAC ATTGCAACTA TTGTGGCAGA CAAATGTGTG AATCCTGAAA CAAAGAGACC ATACACCGTG ATCCTTATTG AGAGAGCCAT GAAGGACATC CACTATTCGG TGAAAACCAA CAAGAGTACA AAACAGCAGG CTTTGGAAGT GATAAAGCAG TTAAAAGAGA AAATGAAGAT AGAACGTGCT CACATGAGGC TTCGGTTCAT CCTTCCAGTC AATGAAGGCA AGAAGCTGAA AGAAAAGCTC AAGCCACTGA TCAAGGTCAT AGAAAGTGAA GATTATGGCC AACAGTTAGA AATCGTATGT CTGATTGACC CGGGCTGCTT CCGAGAAATT GATGAGCTAA TAAAAAAGGA AACTAAAGGC AAAGGTTCTT TGGAAGTACT CAATCTGAAA GATGTAGAAG AAGGAGATGA GAAATTTGAA TGA
Translati on Sequence: MSIFTPTNQI RLTNVAVVRM KRAGKRFEIA CYKNKVVGWR SGVEKDLDEV LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER HTQLEQMFRD IATIVADKCV NPETKRPYTV ILIERAMKDI HYSVKTNKST KQQALEVIKQ LKEKMKIERA HMRLRFILPV NEGKKLKEKL KPLIKVIESE DYGQQLEIVC LIDPGCFREI DELIKKETKG KGSLEVLNLK DVEEGDEKFE
3D Structure
ModBase 3D Structure for Q9Y3A5
Chromosome Location
7q11.21
OMIM Reference Number
607444
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
Preparation and Storage
Store the plasmid at -20 degree C.
Other Notes
Small volumes of SBDS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SBDS cdna clone
SBDS encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its
biological nature has not been determined. This gene has a closely linked pseudogene that is distally located.
Product Categories/Family for SBDS cdna clone
Metabolism
NCBI/Uniprot data below describe general gene information for SBDS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_057122.2
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NCBI GenBank Nucleotide #
NM_016038.2
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UniProt Primary Accession #
Q9Y3A5
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UniProt Related Accession #
Q9Y3A5[Other Products]
NCBI Official Full Name
ribosome maturation protein SBDS
NCBI Official Synonym Full Names
SBDS ribosome maturation factor
NCBI Official Symbol
SBDS??[Similar Products]
NCBI Official Synonym Symbols
SDS; SWDS; CGI-97
??[Similar Products]
NCBI Protein Information
ribosome maturation protein SBDS
UniProt Protein Name
Ribosome maturation protein SBDS
UniProt Synonym Protein Names
Shwachman-Bodian-Diamond syndrome protein
Protein Family
Ribosome maturation protein
UniProt Gene Name
SBDS??[Similar Products]
UniProt Entry Name
SBDS_HUMAN
NCBI Summary for SBDS
This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017]
UniProt Comments for SBDS
SBDS: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS). SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities. Belongs to the SDO1/SBDS family.
Protein type: Nucleolus
Chromosomal Location of Human Ortholog: 7q11.21
Cellular Component: nucleoplasm; spindle pole; cytoplasm; nucleolus; nucleus
Molecular Function: rRNA binding; protein binding; microtubule binding; ribosome binding
Biological Process: bone marrow development; cell proliferation; leukocyte chemotaxis; ribosomal large subunit biogenesis and assembly; mitotic spindle stabilization; inner cell mass cell proliferation; rRNA processing; mature ribosome assembly; bone mineralization
Disease: Shwachman-diamond Syndrome; Aplastic Anemia
Research Articles on SBDS
1. SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment.
Precautions
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Disclaimer
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