Product Name
Ldlrap1, Polyclonal Antibody
Full Product Name
Ldlrap1 Antibody - C-terminal region
Product Gene Name
anti-LDLRAP1 antibody
[Similar Products]
Product Synonym Gene Name
AA691260; ARH2; Arh; Arh1; FHCB1; FHCB2[Similar Products]
Antibody/Peptide Pairs
Ldlrap1 peptide (MBS3237097) is used for blocking the activity of Ldlrap1 antibody (MBS3212150)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: APLSTVSANT NNVDETPRPQ VLGNNSVVWE LDDGLDEAFS RLAQSRTNPQ
3D Structure
ModBase 3D Structure for Q8C142
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Ldlrap1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-LDLRAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LDLRAP1 antibody
This is a rabbit polyclonal antibody against Ldlrap1. It was validated on Western Blot
Target Description: Ldlrap1 is an adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). It may be required for LDL binding and internalization but not for receptor clustering in coated pits. It may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. Ldlrap1 may also be involved in the internalization of other LDLR family members. Ldlrap1 binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
Product Categories/Family for anti-LDLRAP1 antibody
Polyclonal;
Applications Tested/Suitable for anti-LDLRAP1 antibody
Western Blot (WB)
Western Blot (WB) of anti-LDLRAP1 antibody
Host: Rabbit
Target Name: Ldlrap1
Sample Type: Mouse Testis lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for LDLRAP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_663529
[Other Products]
NCBI GenBank Nucleotide #
NM_145554
[Other Products]
UniProt Primary Accession #
Q8C142
[Other Products]
UniProt Related Accession #
Q8C142[Other Products]
NCBI Official Full Name
low density lipoprotein receptor adapter protein 1
NCBI Official Synonym Full Names
low density lipoprotein receptor adaptor protein 1
NCBI Official Symbol
Ldlrap1??[Similar Products]
NCBI Official Synonym Symbols
Arh; ARH2; Arh1; FHCB1; FHCB2; AA691260
??[Similar Products]
NCBI Protein Information
low density lipoprotein receptor adapter protein 1
UniProt Protein Name
Low density lipoprotein receptor adapter protein 1
UniProt Synonym Protein Names
Autosomal recessive hypercholesterolemia protein homolog
Protein Family
Low density lipoprotein receptor adapter protein
UniProt Gene Name
Ldlrap1??[Similar Products]
UniProt Comments for LDLRAP1
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
Research Articles on LDLRAP1
1. The combination of Arh and Dab2 is responsible for the majority of adaptor function in LDLR endocytosis and LDLR-mediated cholesterol homeostasis.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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