Homo sapiens matrin 3 (MATR3), transcript variant 1; MGC9105; KIAA0723;DKFZp686K0542; DKFZp686K23100

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

2539C3a

Mouse

100 ug/ml (1.0 ml) (lot specific)

Small volumes of anti-MATR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is localized in the nuclear matrix. It may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. Two transcript variants encoding the same protein have been identified for this gene. [NCBI Entrez Gene Summary]

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Western blot analysis of immunized recombinant protein, using anti-MATR3 monoclonal antibody.

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.

Detection of MATR3 by Western blot.

Samples: Whole cell lysate from human HT-1080 (H, 25 ug), mouse NIH3T3 (M, 25 ug) and rat F2408 (R, 25 ug) cells. [Lot No. 2539C3a-1]

Predicted molecular weight: 94 kDa

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-MATR3 mAb. [Lot No. 2539C3a-1]

62,576 Da

matrin 3

matrin-3; vocal cord and pharyngeal weakness with distal myopathy

Matrin-3

MATR3_HUMAN

This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]

matrin 3: an acidic protein that is a component of the nuclear matrix. May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network.

Protein type: RNA-binding; RNA processing

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: nucleoplasm; nuclear matrix; membrane; nuclear inner membrane

Molecular Function: protein binding; zinc ion binding; nucleotide binding; structural molecule activity

Disease: Amyotrophic Lateral Sclerosis 21

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