Anti-HOXD10 Antibody (Internal) IHC-plus; HOXD10; Homeo box 4D; Homeobox protein Hox-D10; Hox-4.4; Homeobox protein Hox-4E; HOX4; Homeobox D10; HOX4D; HOX4E; Homeo box D10; Homeobox protein Hox-4D; Human HOXD10

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Human HOXD10.

Immunoaffinity Purified

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

0.5 mg/ml (lot specific)

Store at -20 degree C. Minimize freezing and thawing.

Small volumes of anti-HOXD10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA (1:32000), IHC-P (3.75 ug/ml), WB (0.2 - 0.6 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Approx. 37 kDa band observed in Human Kidney lysates (calculated MW of 38.4 kDa according to NP_002139.2). Recommended concentration: 0.2-0.6 ug/ml. Additional bands of unknown i...

Anti-HOXD10 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HOXD10 antibody (0.2 ug/ml) staining of Human Kidney lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

38,411 Da

homeobox D10

homeobox protein Hox-D10; homeo box 4D; homeo box D10; homeobox protein Hox-4D; homeobox protein Hox-4E

Homeobox protein Hox-D10

HOX4D; HOX4E??[Similar Products]

HXD10_HUMAN

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

HOXD10: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXD10 are a cause of congenital vertical talus (CVT); also known as rocker-bottom foot deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity. Belongs to the Abd-B homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; chromatin binding; transcription factor activity

Biological Process: forelimb morphogenesis; anterior/posterior pattern formation; peripheral nervous system neuron development; hindlimb morphogenesis; skeletal muscle development; transcription, DNA-dependent; ***** locomotory behavior; neuromuscular process; single fertilization; spinal cord motor neuron cell fate specification; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation; embryonic limb morphogenesis; embryonic skeletal morphogenesis

Disease: Vertical Talus, Congenital

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