For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity Purified

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-GLRA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a rabbit polyclonal antibody against GLRA1. It was validated on Western Blot using a cell lysate as a positive control.

Target Description: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).

Ion Channel; Neurobiology; Receptors;

Western Blot (WB)

WB Suggested Anti-GLRA1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Raji cell lysateGLRA1 is supported by BioGPS gene expression data to be expressed in Raji

51kDa

glycine receptor alpha 1

glycine receptor subunit alpha-1

Glycine receptor subunit alpha-1

GLRA1_HUMAN

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]

GLRA1: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1). A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; Transporter

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: postsynaptic membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membrane; cell junction; external side of plasma membrane

Molecular Function: protein binding; transmitter-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine binding; taurine binding

Biological Process: regulation of action potential; startle response; synaptic transmission, glycinergic; righting reflex; acrosome reaction; chloride transport; neurological control of breathing; ***** walking behavior; regulation of inhibitory postsynaptic membrane potential; neuromuscular process controlling posture; regulation of membrane potential; visual perception; negative regulation of transmission of nerve impulse; muscle contraction; neuropeptide signaling pathway; ion transport; transmembrane transport

Disease: Hyperekplexia, Hereditary 1

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.