Anti -CBL-C, CT (Signal Transduction Protein CBL-C, SH3-binding Protein CBL-C, SH3-binding Protein CBL-3, CBL3, RING Finger Protein 57, RNF57)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 19; NC_000019.9 (45281126..45303903). Location: 19q13.2

Polyclonal

rabbit

Human

Affinity Purified
Purified by immunoaffinity chromatography.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-CBLC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known

Antibodies; Abs to Transcription Factors, Zinc (Ring) Finger

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)

Suitable for use in Immunofluorescence, ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry.
Dilution: ELISA: 1:10,000-1:50,000
Western Blot: 1:500-1:3000
Immunohistochemistry: 5ug/ml

52,456 Da[Similar Products]

Cbl proto-oncogene C, E3 ubiquitin protein ligase

signal transduction protein CBL-C; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cas-Br-M (murine) ecotropic retroviral transforming sequence c

Signal transduction protein CBL-C

CBL3; RNF57??[Similar Products]

CBLC_HUMAN

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Cbl-c: Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleus

Molecular Function: signal transducer activity; phosphotyrosine binding; zinc ion binding; calcium ion binding; SH3 domain binding; ligase activity; epidermal growth factor receptor binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination

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