Product Name
Methionine Sulfoxide Reductase B2 (MSRB2), Recombinant Protein
Full Product Name
Recombinant Human Methionine Sulfoxide Reductase B2
Product Synonym Names
MSRB2 Human; Methionine Sulfoxide Reductase B2 Human Recombinant; CBS-1; PILB; Pilin-like Transcription Factor; MSRB; CGI-131; Mmethionine Sulfoxide Reductase B2; Methionine-R-Sulfoxide Reductase B2 Mitochondrial; MGC26104; MsrB2. EC 1.8.4
Product Gene Name
MSRB2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MVRGQA GGGG PGTGPGLGEA GSLATCELPL AKSEWQKKLT PEQFYVTREK GTEPPFSGIY LNNKEAGMYH CVCCDSPLFS SEKKYCSGTG WPSFSEAHGT SGSDESHTGI LRRLDTSLGS ARTEVVCKQC EAHLGHVFPD GPGPNGQRFC INSVALKFKP RKH
3D Structure
ModBase 3D Structure for Q9Y3D2
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
The MSRB2 protein solution (1mg/1ml) is formulated in In 20 mM Tris-HCl Buffer (pH 7.5), 1 mM DTT, 0.1 mM PMSF and 10% Glycerol.
Sterile Filtered clear solution.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Please avoid freeze thaw cycles.
Other Notes
Small volumes of MSRB2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MSRB2 recombinant protein
Description: MSRB2 produced in E Coli is a single, non-glycosylated polypeptide chain containing 183 amino acids (21-182a.a.) and having a molecular mass of 19.5kDa.MSRB2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: MSRB2 is a member of the methionine sulfoxide reductases(MSRs) family which are antioxidant repair enzymes. MSRB2 protein catalyzes the decrease of free and protein-bound methionine sulfoxide to methionine. MSRB2 has a part in protecting against oxidative stress in numerous organs.
Product Categories/Family for MSRB2 recombinant protein
ENZYMES; Enzymes; Reductase
NCBI/Uniprot data below describe general gene information for MSRB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036360.3
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NCBI GenBank Nucleotide #
NM_012228.3
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UniProt Primary Accession #
Q9Y3D2
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UniProt Secondary Accession #
Q17R44; Q4G1C7; Q9Y5W6[Other Products]
UniProt Related Accession #
Q9Y3D2[Other Products]
Molecular Weight
19,536 Da
NCBI Official Full Name
methionine-R-sulfoxide reductase B2, mitochondrial
NCBI Official Synonym Full Names
methionine sulfoxide reductase B2
NCBI Official Symbol
MSRB2??[Similar Products]
NCBI Official Synonym Symbols
CBS1; MSRB; PILB; CBS-1; CGI-131
??[Similar Products]
NCBI Protein Information
methionine-R-sulfoxide reductase B2, mitochondrial; pilin-like transcription factor
UniProt Protein Name
Methionine-R-sulfoxide reductase B2, mitochondrial
Protein Family
Methionine-R-sulfoxide reductase
UniProt Gene Name
MSRB2??[Similar Products]
UniProt Synonym Gene Names
CBS-1; MSRB; MsrB2??[Similar Products]
UniProt Entry Name
MSRB2_HUMAN
UniProt Comments for MSRB2
MSRB2: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. Belongs to the MsrB Met sulfoxide reductase family.
Protein type: Transcription factor; Oxidoreductase; EC 1.8.4.-; Mitochondrial
Chromosomal Location of Human Ortholog: 10p12
Cellular Component: mitochondrion
Molecular Function: zinc ion binding; peptide-methionine (R)-S-oxide reductase activity; actin binding; transcription factor activity
Biological Process: protein repair; regulation of transcription, DNA-dependent; actin filament polymerization; response to oxidative stress
Research Articles on MSRB2
1. Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
