Product Name
ARL6, cDNA Clone
Full Product Name
ARL6 cDNA Clone
Product Gene Name
ARL6 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggattgc tagacagact ttcagtcttg cttggcctga agaagaagga ggttcatgtt ttgtgccttg ggctagataa tagtggcaaa acgacgatca ttaacaaact taaaccttca aatgctcaat ctcaaaatat ccttccaaca ataggattca gcatagagaa attcaaatca tccagtttgt catttacagt gtttgacatg tcaggtcaag gaagatacag aaatctctgg gaacactatt ataaagaagg ccaagctatt atttttgtca ttgatagtag tgatagatta agaatggttg tggccaaaga agaactcgat actcttctga atcatccaga tattaaacac cgtcgaattc caatcttatt ctttgcaaat aaaatggatc ttagagatgc agtgacatct gtaaaagtgt ctcagttgct gtgtttagag aacatcaaag ataaaccctg gcatatttgt gctagtgatg ccataaaagg agaaggcttg caagaaggtg tagactggct tcaagatcag atccagactg tgaagacatg a
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ARL6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ARL6. It may not necessarily be applicable to this product.
NCBI Accession #
BC024239
[Other Products]
UniProt Secondary Accession #
A8KA93; D3DN31[Other Products]
UniProt Related Accession #
Q9H0F7[Other Products]
Molecular Weight
21,960 Da
NCBI Official Full Name
Homo sapiens ADP-ribosylation factor-like 6, mRNA
NCBI Official Synonym Full Names
ADP ribosylation factor like GTPase 6
NCBI Official Symbol
ARL6??[Similar Products]
NCBI Official Synonym Symbols
BBS3; RP55
??[Similar Products]
NCBI Protein Information
ADP-ribosylation factor-like protein 6
UniProt Protein Name
ADP-ribosylation factor-like protein 6
UniProt Synonym Protein Names
Bardet-Biedl syndrome 3 protein
UniProt Gene Name
ARL6??[Similar Products]
UniProt Synonym Gene Names
BBS3??[Similar Products]
UniProt Entry Name
ARL6_HUMAN
NCBI Summary for ARL6
The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). A vision-specific transcript, encoding long isoform BBS3L, has been described (PMID: 20333246). [provided by RefSeq, Apr 2016]
UniProt Comments for ARL6
ARL6: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization. Defects in ARL6 are a cause of Bardet-Biedl syndrome type 3 (BBS3). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Defects in ARL6 are the cause of retinitis pigmentosa type 55 (RP55). RP55 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the small GTPase superfamily. Arf family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein, monomeric, ARF; G protein, monomeric; G protein
Chromosomal Location of Human Ortholog: 3q11.2
Cellular Component: axoneme; cilium; cytoplasm; membrane; membrane coat; plasma membrane
Molecular Function: phospholipid binding; protein binding
Biological Process: cilium biogenesis; determination of left/right symmetry; melanosome transport; protein polymerization; protein targeting to membrane; Wnt receptor signaling pathway
Disease: Bardet-biedl Syndrome 1; Bardet-biedl Syndrome 3; Retinitis Pigmentosa; Retinitis Pigmentosa 55
Research Articles on ARL6
1. Elevated levels of serum ARL6 were able to discriminate between excessive alcohol users and controls.
Precautions
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Disclaimer
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