Full Product Name
TLL1, CT (TLL1, TLL, Tolloid-like protein 1)
Product Synonym Names
Anti -TLL1, CT (TLL1, TLL, Tolloid-like protein 1)
Product Gene Name
anti-TLL1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 4; NC_000004.11 (166794390..167026330). Location: 4q32-q33
3D Structure
ModBase 3D Structure for O43897
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
TLL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 877-905 amino acids from the C-terminal region of human TLL1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-TLL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TLL1 antibody
This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.
Product Categories/Family for anti-TLL1 antibody
Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-TLL1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TLL1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
NCBI/Uniprot data below describe general gene information for TLL1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001191689.1
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NCBI GenBank Nucleotide #
NM_001204760.1
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UniProt Primary Accession #
O43897
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UniProt Secondary Accession #
Q96AN3; Q9NQS4; B2RMU2[Other Products]
UniProt Related Accession #
O43897[Other Products]
Molecular Weight
114,709 Da[Similar Products]
NCBI Official Full Name
tolloid-like protein 1 isoform 2
NCBI Official Synonym Full Names
tolloid-like 1
NCBI Official Symbol
TLL1??[Similar Products]
NCBI Official Synonym Symbols
TLL; ASD6
??[Similar Products]
NCBI Protein Information
tolloid-like protein 1
UniProt Protein Name
Tolloid-like protein 1
Protein Family
Tolloid-like protein
UniProt Gene Name
TLL1??[Similar Products]
UniProt Synonym Gene Names
TLL??[Similar Products]
UniProt Entry Name
TLL1_HUMAN
NCBI Summary for TLL1
This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
UniProt Comments for TLL1
TLL1: Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Defects in TLL1 are the cause of atrial septal defect type 6 (ASD6). A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Belongs to the peptidase M12A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.24.-
Chromosomal Location of Human Ortholog: 4q32-q33
Cellular Component: extracellular region
Molecular Function: collagen binding; zinc ion binding; metalloendopeptidase activity; calcium ion binding
Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; cell differentiation; proteolysis; skeletal development
Disease: Atrial Septal Defect 6
Research Articles on TLL1
1. TLL-1 gene mutation with an insertion mutation of base A in exon 10 is common in Chinese patients with sporadic congenital heart diseases.
Precautions
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Disclaimer
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