Product Name
ARL6, Polyclonal Antibody
Popular Item
Full Product Name
ARL6 Polyclonal Antibody
Product Synonym Names
BBS3; RP55
Product Gene Name
anti-ARL6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MGLLDRLSVL LGLKKKEVHV LCLGLDNSGK TTIINKLKPS NAQSQNILPT IGFSIEKFKS SSLSFTVFDM SGQGRYRNLW EHYYKEGQAI IFVIDSSDRL RMVVAKEELD TLLNHPDIKH RRIPILFFAN KMDLRDAVTS VKVSQLLCLE NIKDKPWHIC ASDAIKGEGL QEGVDWLQDQ IQTVKT
3D Structure
ModBase 3D Structure for Q9H0F7
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human ARL6
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location
Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cilium axoneme, cilium basal body, cilium membrane, cytoskeleton
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-ARL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARL6 antibody
The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). Alternative splicing results in multiple transcript variants of this gene. A vision-specific transcript encoding a different protein has been described (PMID: 20333246).
Product Categories/Family for anti-ARL6 antibody
Polyclonal Antibodies
Applications Tested/Suitable for anti-ARL6 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-ARL6 antibody
WB: 1:500 - 1:2000
IF: 1:50 - 1:200
NCBI/Uniprot data below describe general gene information for ARL6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001265222.1
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NCBI GenBank Nucleotide #
NM_001278293.2
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UniProt Primary Accession #
Q9H0F7
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UniProt Secondary Accession #
A8KA93; D3DN31[Other Products]
UniProt Related Accession #
Q9H0F7[Other Products]
NCBI Official Full Name
ADP-ribosylation factor-like protein 6 isoform 1
NCBI Official Synonym Full Names
ADP ribosylation factor like GTPase 6
NCBI Official Symbol
ARL6??[Similar Products]
NCBI Official Synonym Symbols
BBS3; RP55
??[Similar Products]
NCBI Protein Information
ADP-ribosylation factor-like protein 6
UniProt Protein Name
ADP-ribosylation factor-like protein 6
UniProt Synonym Protein Names
Bardet-Biedl syndrome 3 protein
UniProt Gene Name
ARL6??[Similar Products]
UniProt Synonym Gene Names
BBS3??[Similar Products]
NCBI Summary for ARL6
The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). A vision-specific transcript, encoding long isoform BBS3L, has been described (PMID: 20333246). [provided by RefSeq, Apr 2016]
UniProt Comments for ARL6
Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization ().
Research Articles on ARL6
1. Mutations of the ARL6 gene cause Bardet-Biedl syndrome, a heterogeneous disorder that increases the risk of Hypertension and Diabetes mellitus.
Precautions
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Disclaimer
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