Product Name
SNX15, cDNA Clone
Full Product Name
SNX15 cDNA Clone
Product Gene Name
SNX15 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtcccgcc aggcgaagga tgacttcctg cggcactaca cagtgtcgga ccccaggact caccccaagg gctacaccga gtacaaagta accgcgcagt tcatctcaaa gaaggaccca gaggatgtca aagaggtggt ggtctggaag cggtacagcg acttccgcaa gctgcatgga gacctggcct acacccaccg caacctcttc cgccgcctcg aggagttccc cgctttcccc cgggcccagg tgtttggccg gtttgaagcc tcagtgatcg aggagcggcg aaagggggca gaggacctgc ttcgcttcac tgtgcacata cctgcgctca acaacagccc ccagctcaag gagttcttcc ggggtgggga ggtgacccga cccttggagg tgtccaggga cctacacatc ctgccacccc ctctgatccc caccccgccc cctgatgacc cccggctatc ccaactgctc cctgcagaaa ggaggggcct cgaggaattg gaggtgccag tggacccccc accatccagc cctgcccagg aggccctgga tctcctcttt aactgtgaga gcaccgagga ggcatctggt tcccctgccc gaggccccct caccgaggct gagcttgccc tcttcgaccc cttctccaag gaagaaggcg cagcccccag ccccacccat gtggctgagc tggcaacgat ggaggtggag tctgcaaggc tggaccagga accctgggag ccaggagggc aggaggagga agaggatggg gaaggagggc ccacccctgc ctacctaagc caggccacag agctcatcac ccaggccctg cgggatgaga aggcaggcgc ttacgctgct gcactccagg gctatcgaga cggcgtgcac gtcttgcttc agggagtccc cagtgacccg ttgcctgccc gccaggaagg tgtgaagaag aaggcagctg agtacctgaa gcgggcagag gagatcctgc gcctgcacct gtctcaactc ccaccctaa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SNX15 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SNX15. It may not necessarily be applicable to this product.
NCBI Accession #
BC009897
[Other Products]
UniProt Secondary Accession #
Q9NRS5; E5KQS6[Other Products]
UniProt Related Accession #
Q9NRS6[Other Products]
Molecular Weight
29,220 Da
NCBI Official Full Name
Homo sapiens sorting nexin 15, mRNA
NCBI Official Synonym Full Names
sorting nexin 15
NCBI Official Symbol
SNX15??[Similar Products]
NCBI Official Synonym Symbols
HSAF001435
??[Similar Products]
NCBI Protein Information
sorting nexin-15
UniProt Protein Name
Sorting nexin-15
Protein Family
Sorting nexin
UniProt Gene Name
SNX15??[Similar Products]
UniProt Entry Name
SNX15_HUMAN
NCBI Summary for SNX15
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]
UniProt Comments for SNX15
SNX15: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleolus
Molecular Function: protein binding; protein serine/threonine kinase activity
Biological Process: signal transduction
Research Articles on SNX15
1. The activated EGF receptor enters distinct sub-populations of SNX15- and APPL1-labelled peripheral endocytic vesicles.
Precautions
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Disclaimer
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