Human Tax1-binding protein 1 (TAX1BP1) ELISA kit; CALCOCO3; T6BP; TXBP151; tax1-binding protein; Tax1 (human T-cell leukemia virus type I) binding protein 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of TAX1BP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9330086 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tax1 (human T-cell leukemia virus type I) binding protein 1 (TAX1BP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TAX1BP1. The ELISA analytical biochemical technique of the MBS9330086 kit is based on TAX1BP1 antibody-TAX1BP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TAX1BP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TAX1BP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

90,877 Da

Tax1 (human T-cell leukemia virus type I) binding protein 1

tax1-binding protein 1; TRAF6-binding protein

Tax1-binding protein 1

T6BP; PRO0105??[Similar Products]

TAXB1_HUMAN

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

TAX1BP1: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Expressed in all tissues tested. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: cytosol

Molecular Function: protein binding; metal ion binding; kinase binding

Biological Process: apoptosis; inhibition of NF-kappaB transcription factor; innate immune response; negative regulation of interferon type I production; negative regulation of apoptosis

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