Full Product Name
CPN1 Antibody
Product Synonym Names
Carboxypeptidase N catalytic chain; CPN; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Lysine carboxypeptidase; Arginine carboxypeptidase; Kininase-1; Serum carboxypeptidase N; SCPN; Anaphylatoxin inactivator; Plasma carboxypeptidase
Product Gene Name
anti-CPN1 antibody
[Similar Products]
Product Synonym Gene Name
CBPN[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15169
Specificity
CPN1 Antibody detects endogenous levels of total CPN1 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human CPN1.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-CPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CPN1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CPN1 antibody
WB: 1:500~1:1000
ELISA: 1:20000
Western Blot (WB) of anti-CPN1 antibody
Western blot analysis of lysates from RAW264.7 cells, using CPN1 Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for CPN1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001299.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001308.2
[Other Products]
UniProt Primary Accession #
P15169
[Other Products]
UniProt Secondary Accession #
B1AP59[Other Products]
UniProt Related Accession #
P15169[Other Products]
NCBI Official Full Name
carboxypeptidase N catalytic chain
NCBI Official Synonym Full Names
carboxypeptidase N subunit 1
NCBI Official Symbol
CPN1??[Similar Products]
NCBI Official Synonym Symbols
CPN; SCPN
??[Similar Products]
NCBI Protein Information
carboxypeptidase N catalytic chain
UniProt Protein Name
Carboxypeptidase N catalytic chain
UniProt Synonym Protein Names
Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN
Protein Family
Carboxypeptidase
UniProt Gene Name
CPN1??[Similar Products]
UniProt Synonym Gene Names
ACBP; CPN; SCPN??[Similar Products]
NCBI Summary for CPN1
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for CPN1
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
Research Articles on CPN1
1. CPN binds to fibrinogen and is present in a fibrin clot prepared from plasma.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
