Product Name
ALKBH3, cDNA Clone
Popular Item
Full Product Name
ALKBH3 cDNA Clone
Product Gene Name
ALKBH3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGGAGGAAA AAAGACGGCG AGCCCGAGTT CAGGGAGCCT GGGCTGCCCC TGTTAAAAGC CAGGCCATTG CTCAGCCAGC TACCACTGCT AAGAGCCATC TCCACCAGAA GCCTGGCCAG ACCTGGAAGA ACAAAGAGCA TCATCTCTCT GACAGAGAGT TTGTGTTCAA AGAACCTCAG CAGGTAGTAC GTAGAGCTCC TGAGCCACGA GTGATTGACA GAGAGGGTGT GTATGAAATC AGCCTGTCAC CCACAGGTGT ATCTAGGGTC TGTTTGTATC CTGGCTTTGT TGACGTGAAA GAAGCTGACT GGATATTGGA ACAGCTTTGT CAAGATGTTC CCTGGAAACA GAGGACCGGC ATCAGAGAGG ATATAACTTA TCAGCAACCA AGACTTACAG CATGGTATGG AGAACTTCCT TACACTTATT CAAGAATCAC TATGGAACCA AATCCTCACT GGCACCCTGT GCTGCGCACA CTAAAGAACC GCATTGAAGA GAACACTGGC CACACCTTCA ACTCCTTACT CTGCAATCTT TATCGCAATG AGAAGGACAG CGTGGACTGG CACAGTGATG ATGAACCCTC ACTAGGGAGG TGCCCCATTA TTGCTTCACT AAGTTTTGGT GCCACACGCA CATTTGAGAT GAGAAAGAAG CCACCACCAG AAGAGAATGG AGAGTACACA TATGTGGAAA GAGTGAAGAT ACCCTTGGAT CATGGGACCT TGTTAATCAT GGAAGGAGCG ACACAAGCTG ACTGGCAGCA TCGAGTGCCC AAAGAATACC ACTCTAGAGA ACCGAGAGTG AACCTGACCT TTCGGACAGT CTATCCAGAC CCTCGAGGGG CACCCTGGTG A
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ALKBH3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ALKBH3. It may not necessarily be applicable to this product.
NCBI Accession #
BC103812
[Other Products]
UniProt Secondary Accession #
Q3SYI0; Q6NX57; Q96BU8; A6NDJ1[Other Products]
UniProt Related Accession #
Q96Q83[Other Products]
Molecular Weight
19,310 Da
NCBI Official Full Name
Homo sapiens alkB, alkylation repair homolog 3 (E. coli), mRNA
NCBI Official Synonym Full Names
alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
NCBI Official Symbol
ALKBH3??[Similar Products]
NCBI Official Synonym Symbols
ABH3; PCA1; DEPC1; hABH3; DEPC-1
??[Similar Products]
NCBI Protein Information
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
UniProt Protein Name
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
UniProt Synonym Protein Names
Alkylated DNA repair protein alkB homolog 3
Protein Family
Alpha-ketoglutarate-dependent dioxygenase
UniProt Gene Name
ALKBH3??[Similar Products]
UniProt Synonym Gene Names
; hABH3??[Similar Products]
UniProt Entry Name
ALKB3_HUMAN
NCBI Summary for ALKBH3
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
UniProt Comments for ALKBH3
ALKBH3: Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-; DNA repair, damage; Oxidoreductase; Hydrolase; Demethylase
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: cytoplasm; mitochondrion; nucleoplasm; nucleus
Molecular Function: DNA-N1-methyladenine dioxygenase activity; ferrous iron binding; protein binding
Biological Process: cell proliferation; DNA dealkylation; DNA repair
Research Articles on ALKBH3
1. Results show that PCA1 expression was positively correlated with advanced stages in renal cell carcinoma and strongly suggest that PCA-1 may be functionally important and a novel molecular target for human renal cell carcinoma.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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