Product Name
ANAPC2, cDNA Clone
Full Product Name
ANAPC2 cDNA Clone
Product Gene Name
ANAPC2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggcgg cagttgtggt ggcggagggg gacagcgact cccggcccgg acaggagttg ttagtggcct ggaacaccgt gagcaccggc ctggtgccgc cggctgcgct ggggctggtg tcttcccgga ccagcggtgc agtcccgcca aaggaagagg agctccgggc ggcggtggag gttctgaggg gccacgggct acactcggtc ctggaggagt ggttcgtgga ggtgctgcag aacgatctgc aggccaacat ctcccctgag ttctggaatg ccatctccca atgcgagaac tctgcggatg agccccagtg ccttttgcta ctccttgacg cttttggcct gctggagagc cgcctggatc cctacctgcg tagcctagag ctgctggaga aatggactcg cctgggcttg ctgatgggca ctggtgctca ggggctgcga gaagaagtcc acactatgtt gcgcggagtc ttgttcttta gcacccccag aaccttccaa gagatgatcc agcgtctgta tgggtgcttc ttgagagtct atatgcagag taagaggaag ggggaagggg gcacagaccc ggaactggaa ggggagctgg acagccggta tgcccgtcgc cggtactacc ggctcctgca gagcccgctg tgtgcagggt gcagcagtga caagcaacag tgctggtgtc gccaggctct ggagcagttc catcagctca gccaggtctt acacaggctc agtctgctgg agcgggtcag tgccgaggct gtgaccacca ccctgcacca ggtgacccgg gagaggatgg aggaccgttg ccggggcgag tacgagcgct ccttcctgcg tgagttccac aagtggatcg agcgggtggt cggctggctc ggcaaggtgt tcctgcagga cggccccgcc aggcccgcat ctcccgaggc cggcaacacc ctgcgccgct ggcgctgcca cgtgcaaagg ttcttctacc gcatctacgc cagcctgcgc atcgaggagc tcttcagcat cgtccgagac ttcccagact cccggccagc catcgaggac ctcaagtact gcctggagag gacggaccag aggcagcagc tgctcgtgtc cctcaaggct gccctggaga ctcggctcct gcatccaggc gtcaacacgt gtgacatcat caccctctat atctctgcca tcaaggcgct gcgcgtgctg gacccttcca tggtcatcct ggaggtggcc tgtgagccta tccgccgcta cctgaggacg cgggaggaca cagtgcggca gattgtggct gggctgacgg gggactcgga cgggacaggg gacctggctg ttgagctgtc caagaccgac ccggcgagcc tggagacagg ccaggacagt gaggatgact caggcgagcc agaggactgg gtcccggacc ctgtggatgc cgatccaggg aagtcgagct ccaagcggcg ttcatcggac atcatcagcc tgctggtcag catctacggc agcaaggacc tcttcatcaa tgagtaccgc tcgctgctgg ccgaccgcct gctgcaccag ttcagcttca gccccgagcg ggagatccgc aacgtggagc tgctgaagct gcgctttggc gaggccccaa tgcacttctg tgaagtcatg ctgaaggaca tggcggactc ccgccgcatc aatgccaaca tccgggagga ggatgagaag cggccagcag aggagcagcc accgttcggg gtctacgctg tcatcctgtc cagtgagttc tggccgccct tcaaggacga gaagctggag gtccccgagg atatcagggc agccctggag gcttactgca agaagtatga gcagctcaag gccatgcgga ccctcagttg gaagcacacc ctgggcctgg tgaccatgga cgtggagctg gccgaccgca cgctgtctgt ggcggtcacc ccagtacagg cggtgatctt gctgtatttt caggaccaag ccagctggac cctggaggaa ctgagcaagg cggtgaagat gcccgtggcg ctgctgcggc ggcggatgtc cgtgtggctg cagcagggtg tgctgcgtga ggagcccccc ggcaccttct ctgtcattga ggaggagcgg cctcaggacc gggacaacat ggtgctcatt gacagtgacg acgagagcga ctccggcatg gcctcccagg ccgaccagaa ggaggaggag ctgctgctct tctggacgta catccaggcc atgctgacca acctggagag cctctcactg gatcgtatct acaacatgct ccgcatgttt gtggtgactg ggcctgcact ggccgagatt gacctgcagg agctgcaggg ctacctgcag aagaaggtgc gggaccagca gctcgtctac tcggccggcg tctaccgcct gcccaagaac tgcagctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ANAPC2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ANAPC2. It may not necessarily be applicable to this product.
NCBI Accession #
BC032503
[Other Products]
UniProt Secondary Accession #
Q5VSG1; Q96DG5; Q96GG4; Q9P2E1[Other Products]
UniProt Related Accession #
Q9UJX6[Other Products]
Molecular Weight
93,469 Da
NCBI Official Full Name
Homo sapiens anaphase promoting complex subunit 2, mRNA
NCBI Official Synonym Full Names
anaphase promoting complex subunit 2
NCBI Official Symbol
ANAPC2??[Similar Products]
NCBI Official Synonym Symbols
APC2
??[Similar Products]
NCBI Protein Information
anaphase-promoting complex subunit 2
UniProt Protein Name
Anaphase-promoting complex subunit 2
UniProt Synonym Protein Names
Cyclosome subunit 2
Protein Family
Anaphase-promoting complex
UniProt Gene Name
ANAPC2??[Similar Products]
UniProt Synonym Gene Names
APC2; KIAA1406; APC2??[Similar Products]
UniProt Entry Name
ANC2_HUMAN
NCBI Summary for ANAPC2
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]
UniProt Comments for ANAPC2
APC2: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the cullin family. The APC/C is composed of at least 12 subunits. Interacts through the cullin domain with ANAPC11 and with UBCH10. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: anaphase-promoting complex; cytosol; nucleoplasm
Molecular Function: ubiquitin protein ligase binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of synaptic plasticity; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Research Articles on ANAPC2
1. The regulation of Mdm2 by the E3 ubiquitin ligase APC/C is shown. It has important therapeutic implications for tumors with Mdm2 overexpression.
Precautions
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Disclaimer
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