Product Name
Coagulation factor VII (F7), Protein
Full Product Name
Coagulation factor VII
Product Synonym Names
Cf7; Serum prothrombin conversion accelerator
Product Gene Name
F7 protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
42-193aa
3D Structure
ModBase 3D Structure for P70375
Purity/Purification
>95% by SDS-PAGE
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of F7 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for F7 protein
Immunology
Applications Tested/Suitable for F7 protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
NCBI/Uniprot data below describe general gene information for F7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_034302.2
[Other Products]
NCBI GenBank Nucleotide #
NM_010172.4
[Other Products]
UniProt Primary Accession #
P70375
[Other Products]
UniProt Secondary Accession #
Q61109[Other Products]
UniProt Related Accession #
P70375[Other Products]
Molecular Weight
50,276 Da
NCBI Official Full Name
coagulation factor VII preproprotein
NCBI Official Synonym Full Names
coagulation factor VII
NCBI Official Symbol
F7??[Similar Products]
NCBI Official Synonym Symbols
Cf7; FVII; AI132620
??[Similar Products]
NCBI Protein Information
coagulation factor VII
UniProt Protein Name
Coagulation factor VII
UniProt Synonym Protein Names
Serum prothrombin conversion accelerator
Protein Family
Coagulation factor
UniProt Gene Name
F7??[Similar Products]
UniProt Synonym Gene Names
Cf7??[Similar Products]
NCBI Summary for F7
This gene encodes a vitamin K-dependent serine protease that plays a critical role in the extrinsic pathway of blood coagulation. Upon contact with tissue factor III (TF III), the encoded protein forms an activated complex termed TF-FVIIa that initiates the coagulation cascade involving other coagulation factors, ultimately resulting in a fibrin clot. Complete lack of the encoded protein in mice results in in perinatal lethality due to bleeding from normal blood vessels. [provided by RefSeq, Apr 2015]
UniProt Comments for F7
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium ().
Research Articles on F7
1. Leu8 is crucial for FVIIa-EPCR binding; this study characterizes its interaction in vivo in mice
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
