Product Name
ACSL5, cDNA Clone
Full Product Name
ACSL5 cDNA Clone
Product Gene Name
ACSL5 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcttttta tctttaactt tttgttttcc ccacttccga ccccggcgtt gatctgcatc ctgacatttg gagctgccat cttcttgtgg ctgatcacca gacctcaacc cgtcttacct cttcttgacc tgaacaatca gtctgtggga attgagggag gagcacggaa gggggtttcc cagaagaaca atgacctaac aagttgctgc ttctcagatg ccaagactat gtatgaggtt ttccaaagag gactcgctgt gtctgacaat gggccctgct tgggatatag aaaaccaaac cagccctaca gatggctatc ttacaaacag gtgtctgata gagcagagta cctgggttcc tgtctcttgc ataaaggtta taaatcatca ccagaccagt ttgtcggcat ctttgctcag aataggccag agtggatcat ctccgaattg gcttgttaca cgtactctat ggtagctgta cctctgtatg acaccttggg accagaagcc atcgtacata ttgtcaacaa ggctgatatc gccatggtga tctgtgacac accccaaaag gcattggtgc tgatagggaa tgtagagaaa ggcttcaccc cgagcctgaa ggtgatcatc cttatggacc cctttgatga tgacctgaag caaagagggg agaagagtgg aattgagatc ttatccctat atgatgctga gaacctaggc aaagagcact tcagaaaacc tgtgcctcct agcccagaag acctgagcgt catctgcttc accagtggga ccacaggtga ccccaaagga gccatgataa cccatcaaaa tattgtttca aatgctgctg cctttctcaa atgtgtggag catgcttatg agcccactcc tgatgatgtg gccatatcct acctccctct ggctcatatg tttgagagga ttgtacaggc tgttgtgtac agctgtggag ccagagttgg attcttccaa ggggatattc ggttgctggc tgacgacatg aagactttga agcccacatt gtttcccgcg gtgcctcgac tccttaacag gatctacgat aaggtacaaa atgaggccaa gacacccttg aagaagttct tgttgaagct ggctgtttcc agtaaattca aagagcttca aaagggtatc atcaggcatg atagtttctg ggacaagctc atctttgcaa agatccagga cagcctgggc ggaagggttc gtgtaattgt cactggagct gcccccatgt ccacttcagt catgacattc ttccgggcag caatgggatg tcaggtgtat gaagcttatg gtcaaacaga atgcacaggt ggctgtacat ttacattacc tggggactgg acatcaggtc acgttggggt gcccctggct tgcaattacg tgaagctgga agatgtggct gacatgaact actttacagt gaataatgaa ggagaggtct gcatcaaggg tacaaacgtg ttcaaaggat acctgaagga ccctgagaag acacaggaag ccctggacag tgatggctgg cttcacacag gagacattgg tcgctggctc ccgaatggaa ctctgaagat catcgaccgt aaaaagaaca ttttcaagct ggcccaagga gaatacattg caccagagaa gatagaaaat atctacaaca ggagtcaacc agtgttacaa atttttgtac acggggagag cttacggtca tccttagtag gagtggtggt tcctgacaca gatgtacttc cctcatttgc agccaagctt ggggtgaagg gctcctttga ggaactgtgc caaaaccaag ttgtaaggga agccatttta gaagacttgc agaaaattgg gaaagaaagt ggccttaaaa cttttgaaca ggtcaaagcc atttttcttc atccagagcc attttccatt gaaaatgggc tcttgacacc aacattgaaa gcaaagcgag gagagctttc caaatacttt cggacccaaa ttgacagcct gtatgagcac atccaggatt ag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ACSL5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ACSL5. It may not necessarily be applicable to this product.
NCBI Accession #
BC007985
[Other Products]
UniProt Secondary Accession #
Q6UX44; Q9UIU4; A6GV77; D3DRB3[Other Products]
UniProt Related Accession #
Q9ULC5[Other Products]
Molecular Weight
73,278 Da
NCBI Official Full Name
Homo sapiens acyl-CoA synthetase long-chain family member 5, mRNA
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 5
NCBI Official Symbol
ACSL5??[Similar Products]
NCBI Official Synonym Symbols
ACS2; ACS5; FACL5
??[Similar Products]
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 5
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 5
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 5; LACS 5
Protein Family
Long-chain-fatty-acid--CoA ligase
UniProt Gene Name
ACSL5??[Similar Products]
UniProt Synonym Gene Names
ACS5; FACL5; LACS 5??[Similar Products]
UniProt Entry Name
ACSL5_HUMAN
NCBI Summary for ACSL5
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACSL5
ACSL5: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. It was suggested that it may also stimulate fatty acid oxidation. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. Belongs to the ATP-dependent AMP-binding enzyme family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; EC 6.2.1.3; Lipid Metabolism - fatty acid; Mitochondrial; Ligase
Chromosomal Location of Human Ortholog: 10q25.2
Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrion; nucleolus; nucleus
Molecular Function: long-chain-fatty-acid-CoA ligase activity
Research Articles on ACSL5
1. ACSL5 mediates antiproliferative activities via Wnt2B palmitoylation with diminished Wnt activity. The molecular pathway is probably relevant for intestinal homeostasis, overwhelmed by other pathways in carcinogenesis.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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