Product Name
Aladin (AAAS), Recombinant Protein
Full Product Name
Recombinant Human Aladin (AAAS)
Product Gene Name
AAAS recombinant protein
[Similar Products]
Product Synonym Gene Name
AAAS[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-546aa, Full Length of Mature Protein
Sequence
CSLGLFPPPP PRGQVTLYEH NNELVTGSSY ESPPPDFRGQ WINLPVLQLT KDPLKTPGRL DHGTRTAFIH HREQVWKRCI NIWRDVGLFG VLNEIANSEE EVFEWVKTAS GWALALCRWA SSLHGSLFPH LSLRSEDLIA EFAQVTNWSS CCLRVFAWHP HTNKFAVALL DDSVRVYNAS STIVPSLKHR LQRNVASLAW KPLSASVLAV ACQSCILIWT LDPTSLSTRP SSGCAQVLSH PGHTPVTSLA WAPSGGRLLS ASPVDAAIRV WDVSTETCVP LPWFRGGGVT NLLWSPDGSK ILATTPSAVF RVWEAQMWTC ERWPTLSGRC QTGCWSPDGS RLLFTVLGEP LIYSLSFPER CGEGKGCVGG AKSATIVADL SETTIQTPDG EERLGGEAHS MVWDPSGERL AVLMKGKPRV QDGKPVILLF RTRNSPVFEL LPCGIIQGEP GAQPQLITFH PSFNKGALLS VGWSTGRIAH IPLYFVNAQF PRFSPVLGRA QEPPAGGGGS IHDLPLFTET SPTSAPWDPL PGPPPVLPHS PHSHL
3D Structure
ModBase 3D Structure for Q9NRG9
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of AAAS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AAAS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001166937.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001173466.1
[Other Products]
UniProt Primary Accession #
Q9NRG9
[Other Products]
UniProt Secondary Accession #
Q5JB47; Q9NWI6; Q9UG19[Other Products]
UniProt Related Accession #
Q9NRG9[Other Products]
Molecular Weight
55,814 Da
NCBI Official Full Name
aladin isoform 2
NCBI Official Synonym Full Names
aladin WD repeat nucleoporin
NCBI Official Symbol
AAAS??[Similar Products]
NCBI Official Synonym Symbols
AAA; AAASb; GL003; ALADIN; ADRACALA; ADRACALIN
??[Similar Products]
NCBI Protein Information
aladin
UniProt Protein Name
Aladin
UniProt Synonym Protein Names
Adracalin
UniProt Gene Name
AAAS??[Similar Products]
UniProt Synonym Gene Names
ADRACALA??[Similar Products]
NCBI Summary for AAAS
The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for AAAS
Plays a role in the normal development of the peripheral and central nervous system.
Research Articles on AAAS
1. C, p.(Trp252Ser) in a French cohort of Triple A syndrome patients.">Nine different AAAS mutations were found, including one new mutation: c.755G>C, p.(Trp252Ser) in a French cohort of Triple A syndrome patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
