Product Name
14-3-3 sigma, Blocking Peptide
Full Product Name
14-3-3 sigma Blocking Peptide
Product Gene Name
14-3-3 sigma blocking peptide
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31947
Other Notes
Small volumes of 14-3-3 sigma blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for 14-3-3 sigma. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006133.1
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NCBI GenBank Nucleotide #
NM_006142.4
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UniProt Primary Accession #
P31947
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UniProt Secondary Accession #
Q6FH30; Q6FH51; Q96DH0[Other Products]
UniProt Related Accession #
P31947[Other Products]
Molecular Weight
24,336 Da
NCBI Official Full Name
14-3-3 protein sigma
NCBI Official Synonym Full Names
stratifin
NCBI Official Symbol
SFN??[Similar Products]
NCBI Official Synonym Symbols
YWHAS
??[Similar Products]
NCBI Protein Information
14-3-3 protein sigma
UniProt Protein Name
14-3-3 protein sigma
UniProt Synonym Protein Names
Epithelial cell marker protein 1; Stratifin
UniProt Gene Name
SFN??[Similar Products]
UniProt Synonym Gene Names
HME1??[Similar Products]
NCBI Summary for 14-3-3 sigma
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]
UniProt Comments for 14-3-3 sigma
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Research Articles on 14-3-3 sigma
1. Review/Meta-analysis: 14-3-3 sigma promoter methylation may be associated with the carcinogenesis of breast cancer and might represent a useful blood-based biomarker for the clinical diagnosis of breast cancer.
Precautions
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Disclaimer
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