Monoclonal PVRL1; Anti-PVRL1; Poliovirus receptor related 1; Herpesvirus entry mediator C; PRR1; CLPED1; OFC7; PVRR1; PVRL1; PVRL 1; PVRL-1

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

6D12

Mouse

PVRL1 antibody was purified by affinity chromatography.

Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

500 ug-1 mg/ml (lot specific)

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of anti-PVRL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mouse monoclonal PVRL1 antibody

Cell Biology

Western Blot (WB)

WB: 1:2000

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant PVRL1 protein (Right) or empty vector (Left) detected with PVRL1 antibody

39,150 Da

poliovirus receptor-related 1 (herpesvirus entry mediator C)

nectin-1

Nectin-1

HVEC; PRR1; Herpesvirus entry mediator C; HveC; HIgR??[Similar Products]

PVRL1_HUMAN

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

nectin 1: Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI); also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDMI is an autosomal recessive syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails. Defects in PVRL1 are the cause of non-syndromic orofacial cleft type 7 (OFC7). Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two- third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Belongs to the nectin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: presynaptic membrane; cell-cell adherens junction; adherens junction; membrane; intracellular membrane-bound organelle; axon; plasma membrane; extracellular region; integral to membrane; catenin complex

Molecular Function: viral receptor activity; protein binding; protein homodimerization activity; protein heterodimerization activity; virion binding; coreceptor activity; cell adhesion molecule binding; carbohydrate binding

Biological Process: intercellular junction assembly and maintenance; axon guidance; entry of virus into host cell; signal transduction; iron ion transport; heterophilic cell adhesion; cell-cell adhesion; regulation of synaptogenesis; retina development in camera-type eye; immune response; lens morphogenesis in camera-type eye; cell adhesion; homophilic cell adhesion

Disease: Cleft Lip/palate-ectodermal Dysplasia Syndrome

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